2021 American Athletic Conference Leaders Rushing Defense - In The 4th Quarter through 01/10/2022
| Name | G | Att | Yards | Avg. | TD | Long | 1st | 10+ | 20+ | |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | SMU | 12 | 117 | 385 | 3.29 | 2 | 21 | 16 | 13 | 2 |
| 2 | Houston | 14 | 113 | 351 | 3.11 | 4 | 44 | 19 | 11 | 3 |
| 2 | Navy | 12 | 104 | 380 | 3.65 | 6 | 24 | 23 | 16 | 3 |
| 4 | Tulsa | 13 | 108 | 428 | 3.96 | 4 | 38 | 24 | 15 | 4 |
| 5 | Tulane | 12 | 133 | 449 | 3.38 | 7 | 35 | 24 | 13 | 5 |
| 5 | Cincinnati | 14 | 167 | 682 | 4.08 | 5 | 37 | 39 | 20 | 5 |
| 7 | UCF | 13 | 111 | 489 | 4.41 | 5 | 32 | 26 | 18 | 6 |
| 7 | Memphis | 12 | 128 | 558 | 4.36 | 5 | 44 | 30 | 17 | 6 |
| 7 | Temple | 12 | 153 | 699 | 4.57 | 10 | 58 | 37 | 20 | 6 |
| 10 | East Carolina | 12 | 94 | 589 | 6.27 | 6 | 90 | 27 | 18 | 7 |
| 11 | South Florida | 12 | 120 | 712 | 5.93 | 7 | 80 | 31 | 19 | 9 |
| 1st: First Downs; 10+: Rush attempts of 10 or more yards; 20+: Rush attempts of 20 or more yards | ||||||||||