2021 American Athletic Conference Leaders Rushing - Games vs. FBS Power 5 Conference Teams Only through 01/10/2022
| Name | Team | Yr | Pos | G | Att | Yards | Avg. | TD | Att/G | Yards/G | |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Isaiah Bowser | UCF | SR | RB | 2 | 41 | 192 | 4.68 | 2 | 20.50 | 96.00 |
| 1 | Jerome Ford | Cincinnati | JR | RB | 2 | 35 | 143 | 4.09 | 2 | 17.50 | 71.50 |
| 1 | Jaren Mangham | S Florida | JR | RB | 2 | 13 | 55 | 4.23 | 2 | 6.50 | 27.50 |
| 4 | Ulysses Bentley IV | SMU | SO | RB | 1 | 20 | 153 | 7.65 | 1 | 20.00 | 153.00 |
| 4 | Edward Saydee | Temple | FR | RB | 2 | 18 | 82 | 4.56 | 1 | 9.00 | 41.00 |
| 4 | Tanner Mordecai | SMU | JR | QB | 1 | 4 | 37 | 9.25 | 1 | 4.00 | 37.00 |
| 4 | Deneric Prince | Tulsa | JR | RB | 2 | 25 | 72 | 2.88 | 1 | 12.50 | 36.00 |
| 4 | Cameron Carroll | Tulane | SO | RB | 2 | 19 | 71 | 3.74 | 1 | 9.50 | 35.50 |
| 4 | Clayton Tune | Houston | JR | QB | 2 | 20 | 71 | 3.55 | 1 | 10.00 | 35.50 |
| 4 | Michael Pratt | Tulane | FR | QB | 2 | 26 | 71 | 2.73 | 1 | 13.00 | 35.50 |
| 4 | Anthony Watkins | Tulsa | SO | RB | 2 | 8 | 53 | 6.63 | 1 | 4.00 | 26.50 |
| 4 | Desmond Ridder | Cincinnati | SR | QB | 2 | 20 | 39 | 1.95 | 1 | 10.00 | 19.50 |
| 4 | Dillon Gabriel | UCF | JR | QB | 1 | 10 | 18 | 1.80 | 1 | 10.00 | 18.00 |
| 4 | D'Wan Mathis | Temple | FR | QB | 1 | 9 | 6 | 0.67 | 1 | 9.00 | 6.00 |
| 4 | Jaetavian Toles | Tulane | SR | WR | 2 | 2 | 10 | 5.00 | 1 | 1.00 | 5.00 |
| 4 | Holton Ahlers | ECU | JR | QB | 1 | 10 | 4 | 0.40 | 1 | 10.00 | 4.00 |