2021 American Athletic Conference Leaders Passes Defended - Games vs. Ranked Teams Only (AP Poll) through 01/10/2022
| Name | Team | Yr | Pos | G | Int. | Passes Broken Up | Passes Defended | Passes Defended/G | |
|---|---|---|---|---|---|---|---|---|---|
| 1 | Warren Saba | ECU | SR | SAF | 2 | 2 | 1 | 3 | 1.50 |
| 1 | Macon Clark | Tulane | JR | S | 4 | 2 | 0 | 2 | 0.50 |
| 3 | Bryan Cook | Cincinnati | SR | S | 3 | 1 | 3 | 4 | 1.33 |
| 3 | Jadon Canady | Tulane | FR | DB | 4 | 1 | 2 | 3 | 0.75 |
| 3 | TieNeal Martin | Tulsa | SR | S | 4 | 1 | 2 | 3 | 0.75 |
| 3 | Ahmad Gardner | Cincinnati | JR | CB | 3 | 1 | 1 | 2 | 0.67 |
| 3 | Joel Dublanko | Cincinnati | SR | LB | 3 | 1 | 1 | 2 | 0.67 |
| 3 | Christian Williams | S Florida | SO | S | 3 | 1 | 1 | 2 | 0.67 |
| 3 | JJ Russell | Memphis | SR | LB | 1 | 1 | 0 | 1 | 1.00 |
| 3 | Rodney Owens | Memphis | SR | DB | 1 | 1 | 0 | 1 | 1.00 |
| 3 | Deshawn Pace | Cincinnati | SO | LB | 3 | 1 | 0 | 1 | 0.33 |
| 3 | Matthew Hill | S Florida | SO | S | 3 | 1 | 0 | 1 | 0.33 |
| 3 | Jaise Oliver | Tulsa | SO | S | 3 | 1 | 0 | 1 | 0.33 |
| 3 | Jamal Glenn | Navy | SR | CB | 3 | 1 | 0 | 1 | 0.33 |
| 3 | Justin Wright | Tulsa | JR | LB | 4 | 1 | 0 | 1 | 0.25 |
| 3 | Travon Fuller | Tulsa | SR | CB | 4 | 1 | 0 | 1 | 0.25 |