2021 American Athletic Conference Leaders Total Offense - Games vs. Conference Teams Only through 01/10/2022
| Name | Team | Yr | Pos | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Desmond Ridder | Cincinnati | SR | QB | 9 | 263 | 2145 | 310 | 2408 | 7.77 | 267.6 |
| 2 | Clayton Tune | Houston | JR | QB | 9 | 35 | 2490 | 347 | 2525 | 7.28 | 280.6 |
| 3 | Tyjae Spears | Tulane | FR | RB | 8 | 814 | 0 | 114 | 814 | 7.14 | 101.8 |
| 4 | Seth Henigan | Memphis | FR | QB | 7 | 162 | 2152 | 335 | 2314 | 6.91 | 330.6 |
| 5 | Holton Ahlers | ECU | JR | QB | 8 | 194 | 2152 | 349 | 2346 | 6.72 | 293.3 |
| 6 | Tanner Mordecai | SMU | JR | QB | 8 | 81 | 2360 | 369 | 2441 | 6.62 | 305.1 |
| 7 | Jerome Ford | Cincinnati | JR | RB | 8 | 872 | 0 | 133 | 872 | 6.56 | 109.0 |
| 8 | Davis Brin | Tulsa | JR | QB | 8 | 44 | 1750 | 285 | 1794 | 6.29 | 224.3 |
| 9 | Keaton Mitchell | ECU | FR | RB | 8 | 780 | 0 | 129 | 780 | 6.05 | 97.5 |
| 10 | Michael Pratt | Tulane | FR | QB | 8 | 56 | 1499 | 271 | 1555 | 5.74 | 194.4 |
| 11 | Johnny Richardson | UCF | SO | RB | 8 | 412 | 0 | 72 | 412 | 5.72 | 51.5 |
| 12 | Mikey Keene | UCF | FR | QB | 8 | -50 | 1323 | 242 | 1273 | 5.26 | 159.1 |
| 13 | Timmy McClain | S Florida | FR | QB | 7 | 105 | 1330 | 274 | 1435 | 5.24 | 205.0 |
| 14 | Alton McCaskill | Houston | FR | RB | 9 | 670 | 0 | 132 | 670 | 5.08 | 74.4 |
| 15 | Cameron Carroll | Tulane | SO | RB | 8 | 392 | 0 | 78 | 392 | 5.03 | 49.0 |
| 16 | Tre Siggers | SMU | SR | RB | 7 | 470 | 0 | 95 | 470 | 4.95 | 67.1 |
| 17 | Ta'Zhawn Henry | Houston | JR | RB | 9 | 454 | 0 | 93 | 454 | 4.88 | 50.4 |
| 18 | Shamari Brooks | Tulsa | SR | RB | 8 | 630 | 0 | 140 | 630 | 4.50 | 78.8 |
| 19 | Jaren Mangham | S Florida | JR | RB | 8 | 503 | 0 | 114 | 503 | 4.41 | 62.9 |
| 20 | Rodrigues Clark | Memphis | JR | RB | 6 | 214 | 40 | 59 | 254 | 4.31 | 42.3 |
| 21 | Justin Lynch | Temple | FR | QB | 7 | 195 | 414 | 144 | 609 | 4.23 | 87.0 |
| 22 | Isaac Ruoss | Navy | SR | FB | 8 | 463 | 0 | 119 | 463 | 3.89 | 57.9 |
| 23 | Tai Lavatai | Navy | SO | QB | 7 | 298 | 359 | 173 | 657 | 3.80 | 93.9 |
| 24 | Rahjai Harris | ECU | FR | RB | 8 | 430 | 0 | 121 | 430 | 3.55 | 53.8 |
| 24 | James Harris II | Navy | SR | FB | 8 | 270 | 0 | 76 | 270 | 3.55 | 33.8 |
Note: To qualify, player must have played in 75% of his team's games and have a minimum of 9.0 plays per game played.