2021 Atlantic Coast Conference Leaders Interceptions - Games in November Only through 01/10/2022
| Name | G | Int. | Yards | TD | Int./G | |
|---|---|---|---|---|---|---|
| 1 | Florida State | 4 | 7 | 77 | 0 | 1.75 |
| 2 | North Carolina State | 4 | 6 | 5 | 1 | 1.50 |
| 3 | Clemson | 4 | 5 | 2 | 0 | 1.25 |
| 3 | Wake Forest | 4 | 5 | 1 | 0 | 1.25 |
| 5 | North Carolina | 4 | 4 | 30 | 0 | 1.00 |
| 5 | Virginia | 3 | 3 | 33 | 0 | 1.00 |
| 7 | Pittsburgh | 4 | 3 | 15 | 0 | 0.75 |
| 8 | Miami (Florida) | 4 | 2 | 32 | 0 | 0.50 |
| 8 | Virginia Tech | 4 | 2 | 21 | 0 | 0.50 |
| 8 | Boston College | 4 | 2 | 0 | 0 | 0.50 |
| 11 | Syracuse | 3 | 1 | 5 | 0 | 0.33 |
| 12 | Louisville | 4 | 1 | 27 | 0 | 0.25 |
| 12 | Duke | 4 | 1 | 8 | 0 | 0.25 |