2021 Atlantic Coast Conference Leaders Interceptions - Games in October Only through 01/10/2022
| Name | G | Int. | Yards | TD | Int./G | |
|---|---|---|---|---|---|---|
| 1 | Pittsburgh | 4 | 6 | 98 | 2 | 1.50 |
| 2 | Florida State | 4 | 5 | 68 | 1 | 1.25 |
| 2 | Louisville | 4 | 5 | 66 | 0 | 1.25 |
| 4 | North Carolina | 4 | 4 | 24 | 0 | 1.00 |
| 4 | North Carolina State | 4 | 4 | 1 | 0 | 1.00 |
| 4 | Miami (Florida) | 3 | 3 | 72 | 1 | 1.00 |
| 7 | Virginia Tech | 4 | 3 | 35 | 1 | 0.75 |
| 7 | Virginia | 4 | 3 | 27 | 0 | 0.75 |
| 7 | Clemson | 4 | 3 | 9 | 0 | 0.75 |
| 10 | Duke | 4 | 2 | 38 | 0 | 0.50 |
| 10 | Boston College | 4 | 2 | 12 | 0 | 0.50 |
| 12 | Syracuse | 5 | 2 | 4 | 0 | 0.40 |
| 13 | Wake Forest | 4 | 1 | 83 | 1 | 0.25 |
| 13 | Georgia Tech | 4 | 1 | 6 | 0 | 0.25 |