2021 Atlantic Coast Conference Leaders Total Offense - Games in November Only through 01/10/2022
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Miami (Florida) | 4 | 411 | 1452 | 297 | 1863 | 6.27 | 465.8 |
| 2 | Pittsburgh | 4 | 608 | 1311 | 314 | 1919 | 6.11 | 479.8 |
| 3 | Wake Forest | 4 | 546 | 1294 | 342 | 1840 | 5.38 | 460.0 |
| 4 | North Carolina State | 4 | 369 | 1272 | 260 | 1641 | 6.31 | 410.3 |
| 5 | Virginia | 3 | 187 | 1102 | 209 | 1289 | 6.17 | 429.7 |
| 6 | Florida State | 4 | 457 | 961 | 276 | 1418 | 5.14 | 354.5 |
| 7 | Louisville | 4 | 914 | 904 | 245 | 1818 | 7.42 | 454.5 |
| 8 | Clemson | 4 | 852 | 876 | 303 | 1728 | 5.70 | 432.0 |
| 9 | North Carolina | 4 | 1023 | 873 | 284 | 1896 | 6.68 | 474.0 |
| 10 | Duke | 4 | 576 | 820 | 314 | 1396 | 4.45 | 349.0 |
| 11 | Virginia Tech | 4 | 1006 | 641 | 244 | 1647 | 6.75 | 411.8 |
| 12 | Boston College | 4 | 762 | 589 | 241 | 1351 | 5.61 | 337.8 |
| 13 | Georgia Tech | 4 | 574 | 493 | 253 | 1067 | 4.22 | 266.8 |
| 14 | Syracuse | 3 | 333 | 329 | 165 | 662 | 4.01 | 220.7 |