2021 Atlantic Coast Conference Leaders Rushing Offense - Games in November Only through 01/10/2022
| Name | G | Att | Yards | Avg. | TD | Att/G | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | North Carolina | 4 | 170 | 1023 | 6.02 | 12 | 42.50 | 255.75 |
| 2 | Clemson | 4 | 176 | 852 | 4.84 | 11 | 44.00 | 213.00 |
| 3 | Louisville | 4 | 147 | 914 | 6.22 | 10 | 36.75 | 228.50 |
| 4 | Wake Forest | 4 | 168 | 546 | 3.25 | 9 | 42.00 | 136.50 |
| 5 | Boston College | 4 | 172 | 762 | 4.43 | 7 | 43.00 | 190.50 |
| 6 | Florida State | 4 | 139 | 457 | 3.29 | 6 | 34.75 | 114.25 |
| 7 | Pittsburgh | 4 | 145 | 608 | 4.19 | 5 | 36.25 | 152.00 |
| 7 | Miami (Florida) | 4 | 131 | 411 | 3.14 | 5 | 32.75 | 102.75 |
| 9 | Georgia Tech | 4 | 142 | 574 | 4.04 | 4 | 35.50 | 143.50 |
| 9 | Virginia | 3 | 77 | 187 | 2.43 | 4 | 25.67 | 62.33 |
| 11 | Virginia Tech | 4 | 165 | 1006 | 6.10 | 3 | 41.25 | 251.50 |
| 11 | Duke | 4 | 163 | 576 | 3.53 | 3 | 40.75 | 144.00 |
| 13 | Syracuse | 3 | 102 | 333 | 3.26 | 2 | 34.00 | 111.00 |
| 14 | North Carolina State | 4 | 114 | 369 | 3.24 | 1 | 28.50 | 92.25 |