2021 Atlantic Coast Conference Leaders Total Offense - Games in October Only through 01/10/2022
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Virginia | 4 | 655 | 1619 | 302 | 2274 | 7.53 | 568.5 |
| 2 | Wake Forest | 4 | 718 | 1523 | 288 | 2241 | 7.78 | 560.3 |
| 3 | Syracuse | 5 | 1365 | 802 | 355 | 2167 | 6.10 | 433.4 |
| 4 | Pittsburgh | 4 | 619 | 1423 | 320 | 2042 | 6.38 | 510.5 |
| 5 | Louisville | 4 | 987 | 905 | 266 | 1892 | 7.11 | 473.0 |
| 6 | North Carolina | 4 | 815 | 1019 | 284 | 1834 | 6.46 | 458.5 |
| 7 | Georgia Tech | 4 | 668 | 1139 | 262 | 1807 | 6.90 | 451.8 |
| 8 | Florida State | 4 | 915 | 673 | 239 | 1588 | 6.64 | 397.0 |
| 9 | North Carolina State | 4 | 452 | 1129 | 249 | 1581 | 6.35 | 395.3 |
| 10 | Virginia Tech | 4 | 714 | 752 | 273 | 1466 | 5.37 | 366.5 |
| 11 | Clemson | 4 | 699 | 745 | 277 | 1444 | 5.21 | 361.0 |
| 12 | Duke | 4 | 597 | 846 | 297 | 1443 | 4.86 | 360.8 |
| 13 | Miami (Florida) | 3 | 316 | 1015 | 221 | 1331 | 6.02 | 443.7 |
| 14 | Boston College | 4 | 327 | 826 | 283 | 1153 | 4.07 | 288.3 |