2021 Atlantic Coast Conference Leaders First Downs - Games vs. Unranked Teams Only (AP Poll) through 01/10/2022
| Name | G | Rush | Pass | Penalty | Total | Total/G | |
|---|---|---|---|---|---|---|---|
| 1 | Wake Forest | 11 | 102 | 144 | 34 | 280 | 25.5 |
| 2 | Miami (Florida) | 8 | 77 | 98 | 27 | 202 | 25.3 |
| 3 | Florida State | 8 | 85 | 70 | 26 | 181 | 22.6 |
| 4 | Pittsburgh | 11 | 102 | 178 | 21 | 301 | 27.4 |
| 5 | North Carolina | 9 | 103 | 91 | 20 | 214 | 23.8 |
| 6 | Clemson | 9 | 86 | 86 | 18 | 190 | 21.1 |
| 7 | Virginia | 8 | 54 | 145 | 17 | 216 | 27.0 |
| 7 | Duke | 10 | 93 | 114 | 17 | 224 | 22.4 |
| 7 | Boston College | 9 | 102 | 67 | 17 | 186 | 20.7 |
| 10 | North Carolina State | 10 | 63 | 122 | 16 | 201 | 20.1 |
| 10 | Virginia Tech | 11 | 111 | 84 | 16 | 211 | 19.2 |
| 12 | Georgia Tech | 8 | 77 | 73 | 15 | 165 | 20.6 |
| 13 | Syracuse | 8 | 92 | 50 | 11 | 153 | 19.1 |
| 14 | Louisville | 8 | 76 | 88 | 10 | 174 | 21.8 |