2021 Atlantic Coast Conference Leaders Scoring Defense - Games vs. FBS Power 5 Conference Teams Only through 01/10/2022
| Name | G | TD | FG | 1XP | 2XP | Safety | Points | Points/G | |
|---|---|---|---|---|---|---|---|---|---|
| 1 | North Carolina State | 9 | 25 | 9 | 25 | 0 | 0 | 202 | 22.4 |
| 1 | Boston College | 9 | 28 | 12 | 27 | 0 | 2 | 235 | 26.1 |
| 1 | Virginia Tech | 10 | 35 | 10 | 33 | 0 | 0 | 273 | 27.3 |
| 1 | Louisville | 10 | 34 | 17 | 31 | 0 | 0 | 286 | 28.6 |
| 1 | Duke | 10 | 54 | 18 | 51 | 0 | 0 | 429 | 42.9 |
| 6 | Clemson | 11 | 21 | 12 | 17 | 1 | 1 | 183 | 16.6 |
| 6 | Pittsburgh | 11 | 35 | 9 | 32 | 1 | 1 | 273 | 24.8 |
| 6 | Wake Forest | 11 | 40 | 14 | 38 | 1 | 0 | 322 | 29.3 |
| 6 | Virginia | 9 | 35 | 14 | 32 | 1 | 1 | 288 | 32.0 |
| 6 | Georgia Tech | 9 | 38 | 14 | 36 | 1 | 0 | 308 | 34.2 |
| 11 | Florida State | 9 | 33 | 8 | 28 | 2 | 0 | 254 | 28.2 |
| 11 | Syracuse | 9 | 31 | 15 | 27 | 2 | 0 | 262 | 29.1 |
| 13 | Miami (Florida) | 10 | 37 | 18 | 34 | 3 | 1 | 318 | 31.8 |
| 14 | North Carolina | 10 | 43 | 13 | 37 | 4 | 0 | 342 | 34.2 |