2021 Atlantic Coast Conference Leaders Passing Defense - Games in November Only through 01/10/2022
| Name | G | Att | Comp | Pct. | Yards | Yards/Att | TD | Int | Rating | Att/G | Yards/G | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | North Carolina State | 4 | 139 | 65 | 46.8 | 736 | 5.3 | 5 | 6 | 94.48 | 34.8 | 184.0 |
| 2 | Clemson | 4 | 141 | 73 | 51.8 | 827 | 5.9 | 1 | 5 | 96.29 | 35.3 | 206.8 |
| 3 | Louisville | 4 | 118 | 76 | 64.4 | 690 | 5.8 | 2 | 1 | 117.42 | 29.5 | 172.5 |
| 4 | Miami (Florida) | 4 | 127 | 79 | 62.2 | 773 | 6.1 | 4 | 2 | 120.59 | 31.8 | 193.3 |
| 5 | Boston College | 4 | 112 | 65 | 58.0 | 690 | 6.2 | 7 | 2 | 126.85 | 28.0 | 172.5 |
| 6 | Wake Forest | 4 | 117 | 68 | 58.1 | 853 | 7.3 | 8 | 5 | 133.38 | 29.3 | 213.3 |
| 7 | Florida State | 4 | 134 | 77 | 57.5 | 996 | 7.4 | 11 | 7 | 136.54 | 33.5 | 249.0 |
| 8 | Virginia Tech | 4 | 121 | 70 | 57.9 | 1035 | 8.6 | 5 | 2 | 140.03 | 30.3 | 258.8 |
| 9 | North Carolina | 4 | 137 | 77 | 56.2 | 1084 | 7.9 | 12 | 4 | 145.72 | 34.3 | 271.0 |
| 10 | Pittsburgh | 4 | 146 | 98 | 67.1 | 1241 | 8.5 | 9 | 3 | 154.75 | 36.5 | 310.3 |
| 11 | Virginia | 3 | 81 | 51 | 63.0 | 658 | 8.1 | 9 | 3 | 160.45 | 27.0 | 219.3 |
| 12 | Syracuse | 3 | 84 | 60 | 71.4 | 731 | 8.7 | 10 | 1 | 181.44 | 28.0 | 243.7 |
| 13 | Duke | 4 | 139 | 92 | 66.2 | 1385 | 10.0 | 14 | 1 | 181.69 | 34.8 | 346.3 |
| 14 | Georgia Tech | 4 | 100 | 67 | 67.0 | 1256 | 12.6 | 11 | 0 | 208.80 | 25.0 | 314.0 |