2021 Atlantic Coast Conference Leaders Scoring Defense - Games vs. FBS Teams With Non-Winning Record Only through 01/10/2022
| Name | G | TD | FG | 1XP | 2XP | Safety | Points | Points/G | |
|---|---|---|---|---|---|---|---|---|---|
| 1 | North Carolina State | 7 | 12 | 8 | 12 | 0 | 0 | 108 | 15.4 |
| 1 | Louisville | 5 | 11 | 7 | 9 | 0 | 0 | 96 | 19.2 |
| 1 | Virginia Tech | 7 | 19 | 7 | 18 | 0 | 0 | 153 | 21.9 |
| 1 | Wake Forest | 9 | 24 | 10 | 23 | 0 | 0 | 197 | 21.9 |
| 1 | Florida State | 6 | 17 | 6 | 14 | 1 | 0 | 136 | 22.7 |
| 1 | Syracuse | 6 | 15 | 12 | 14 | 1 | 0 | 142 | 23.7 |
| 1 | North Carolina | 5 | 18 | 5 | 16 | 2 | 0 | 143 | 28.6 |
| 1 | Georgia Tech | 5 | 19 | 10 | 18 | 1 | 0 | 164 | 32.8 |
| 1 | Duke | 8 | 41 | 10 | 38 | 0 | 0 | 314 | 39.3 |
| 10 | Clemson | 6 | 10 | 5 | 9 | 0 | 1 | 86 | 14.3 |
| 10 | Pittsburgh | 7 | 18 | 4 | 17 | 0 | 1 | 139 | 19.9 |
| 10 | Boston College | 8 | 22 | 6 | 21 | 0 | 1 | 173 | 21.6 |
| 10 | Miami (Florida) | 6 | 20 | 9 | 17 | 3 | 1 | 172 | 28.7 |
| 10 | Virginia | 6 | 21 | 9 | 18 | 1 | 1 | 175 | 29.2 |