2021 Atlantic Coast Conference Leaders Rushing Defense - Games vs. FBS Teams With Non-Winning Record Only through 01/10/2022
| Name | G | Att | Yards | Avg. | TD | Att/G | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Pittsburgh | 7 | 228 | 487 | 2.14 | 5 | 32.57 | 69.57 |
| 2 | Clemson | 6 | 209 | 573 | 2.74 | 5 | 34.83 | 95.50 |
| 3 | Syracuse | 6 | 227 | 925 | 4.07 | 7 | 37.83 | 154.17 |
| 4 | Louisville | 5 | 166 | 686 | 4.13 | 6 | 33.20 | 137.20 |
| 5 | Miami (Florida) | 6 | 240 | 993 | 4.14 | 11 | 40.00 | 165.50 |
| 6 | North Carolina | 5 | 188 | 780 | 4.15 | 8 | 37.60 | 156.00 |
| 7 | Florida State | 6 | 242 | 1020 | 4.21 | 9 | 40.33 | 170.00 |
| 8 | Georgia Tech | 5 | 218 | 932 | 4.28 | 7 | 43.60 | 186.40 |
| 9 | North Carolina State | 7 | 239 | 1051 | 4.40 | 5 | 34.14 | 150.14 |
| 10 | Wake Forest | 9 | 344 | 1662 | 4.83 | 13 | 38.22 | 184.67 |
| 11 | Boston College | 8 | 288 | 1400 | 4.86 | 12 | 36.00 | 175.00 |
| 12 | Virginia Tech | 7 | 264 | 1324 | 5.02 | 10 | 37.71 | 189.14 |
| 13 | Duke | 8 | 300 | 1636 | 5.45 | 16 | 37.50 | 204.50 |
| 14 | Virginia | 6 | 224 | 1441 | 6.43 | 9 | 37.33 | 240.17 |