2021 Atlantic Coast Conference Leaders Rushing Defense - Games vs. Conference Teams Only through 01/10/2022
| Name | G | Att | Yards | Avg. | TD | Att/G | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Pittsburgh | 9 | 299 | 755 | 2.53 | 9 | 33.22 | 83.89 |
| 2 | Clemson | 8 | 308 | 940 | 3.05 | 7 | 38.50 | 117.50 |
| 3 | Louisville | 8 | 270 | 1032 | 3.82 | 9 | 33.75 | 129.00 |
| 4 | Florida State | 8 | 329 | 1311 | 3.98 | 12 | 41.13 | 163.88 |
| 5 | Syracuse | 8 | 291 | 1172 | 4.03 | 10 | 36.38 | 146.50 |
| 6 | North Carolina State | 8 | 277 | 1122 | 4.05 | 9 | 34.63 | 140.25 |
| 7 | Miami (Florida) | 8 | 285 | 1172 | 4.11 | 13 | 35.63 | 146.50 |
| 8 | Georgia Tech | 8 | 342 | 1445 | 4.23 | 12 | 42.75 | 180.63 |
| 9 | North Carolina | 9 | 321 | 1362 | 4.24 | 14 | 35.67 | 151.33 |
| 10 | Virginia Tech | 8 | 305 | 1406 | 4.61 | 13 | 38.13 | 175.75 |
| 11 | Wake Forest | 10 | 386 | 1925 | 4.99 | 19 | 38.60 | 192.50 |
| 12 | Boston College | 8 | 327 | 1651 | 5.05 | 11 | 40.88 | 206.38 |
| 13 | Duke | 8 | 308 | 1747 | 5.67 | 20 | 38.50 | 218.38 |
| 14 | Virginia | 8 | 320 | 1866 | 5.83 | 13 | 40.00 | 233.25 |