2021 Atlantic Coast Conference Leaders Opponent First Downs - Games vs. Non-Conference Teams Only through 01/10/2022
| Name | G | Rush | Pass | Penalty | Total | Total/G | |
|---|---|---|---|---|---|---|---|
| 1 | North Carolina State | 4 | 20 | 40 | 5 | 65 | 16.3 |
| 1 | Georgia Tech | 4 | 34 | 33 | 5 | 72 | 18.0 |
| 1 | Virginia Tech | 5 | 46 | 45 | 5 | 96 | 19.2 |
| 1 | Miami (Florida) | 4 | 33 | 43 | 5 | 81 | 20.3 |
| 5 | Clemson | 5 | 18 | 33 | 6 | 57 | 11.4 |
| 6 | North Carolina | 4 | 54 | 28 | 7 | 89 | 22.3 |
| 7 | Boston College | 4 | 23 | 36 | 8 | 67 | 16.8 |
| 7 | Florida State | 4 | 23 | 42 | 8 | 73 | 18.3 |
| 7 | Duke | 4 | 32 | 42 | 8 | 82 | 20.5 |
| 7 | Virginia | 4 | 36 | 45 | 8 | 89 | 22.3 |
| 7 | Louisville | 5 | 58 | 48 | 8 | 114 | 22.8 |
| 12 | Syracuse | 4 | 34 | 23 | 9 | 66 | 16.5 |
| 13 | Wake Forest | 4 | 42 | 32 | 10 | 84 | 21.0 |
| 14 | Pittsburgh | 5 | 24 | 55 | 12 | 91 | 18.2 |