2021 Atlantic Coast Conference Leaders Scoring Defense - Games vs. Non-Conference Teams Only through 01/10/2022
| Name | G | TD | FG | 1XP | 2XP | Safety | Points | Points/G | |
|---|---|---|---|---|---|---|---|---|---|
| 1 | Virginia | 4 | 15 | 1 | 15 | 0 | 0 | 108 | 27.0 |
| 2 | North Carolina State | 4 | 7 | 3 | 7 | 0 | 0 | 58 | 14.5 |
| 2 | Boston College | 4 | 8 | 3 | 8 | 0 | 0 | 65 | 16.3 |
| 2 | Wake Forest | 4 | 12 | 3 | 11 | 0 | 0 | 92 | 23.0 |
| 5 | Clemson | 5 | 3 | 4 | 3 | 0 | 0 | 33 | 6.6 |
| 5 | Florida State | 4 | 11 | 4 | 10 | 0 | 0 | 88 | 22.0 |
| 5 | Pittsburgh | 5 | 16 | 4 | 13 | 1 | 0 | 123 | 24.6 |
| 5 | Georgia Tech | 4 | 18 | 4 | 17 | 1 | 0 | 139 | 34.8 |
| 9 | Syracuse | 4 | 8 | 5 | 8 | 0 | 0 | 71 | 17.8 |
| 9 | Duke | 4 | 13 | 5 | 11 | 0 | 0 | 104 | 26.0 |
| 9 | Miami (Florida) | 4 | 13 | 5 | 12 | 0 | 0 | 105 | 26.3 |
| 12 | Virginia Tech | 5 | 17 | 6 | 15 | 1 | 0 | 137 | 27.4 |
| 12 | Louisville | 5 | 21 | 6 | 20 | 0 | 0 | 164 | 32.8 |
| 14 | North Carolina | 4 | 13 | 7 | 12 | 1 | 0 | 113 | 28.3 |