2021 Atlantic Coast Conference Leaders Total Offense - Games in December/January Only through 01/10/2022
| Name | Team | Yr | Pos | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Sam Hartman | Wk Forest | SO | QB | 2 | 21 | 517 | 102 | 538 | 5.27 | 269.0 |
| 2 | Malik Cunningham | Louisville | JR | QB | 1 | 66 | 207 | 33 | 273 | 8.27 | 273.0 |
| 2 | Kenny Pickett | Pittsburgh | SR | QB | 1 | 20 | 253 | 39 | 273 | 7.00 | 273.0 |
| 4 | Sam Howell | N Carolina | JR | QB | 1 | 3 | 205 | 33 | 208 | 6.30 | 208.0 |
| 5 | DJ Uiagalelei | Clemson | SO | QB | 1 | 12 | 187 | 38 | 199 | 5.24 | 199.0 |
| 6 | Connor Blumrick | Va Tech | JR | QB | 1 | 11 | 110 | 30 | 121 | 4.03 | 121.0 |
| 7 | Davis Beville | Pittsburgh | SO | QB | 1 | -30 | 149 | 25 | 119 | 4.76 | 119.0 |
| 8 | Trevion Cooley | Louisville | FR | RB | 1 | 92 | 0 | 18 | 92 | 5.11 | 92.0 |
| 9 | Vincent Davis | Pittsburgh | JR | RB | 2 | 82 | 0 | 23 | 82 | 3.57 | 41.0 |
| 10 | Christian Turner | Wk Forest | SO | RB | 2 | 77 | 0 | 16 | 77 | 4.81 | 38.5 |
| 11 | British Brooks | N Carolina | SR | RB | 1 | 72 | 0 | 5 | 72 | 14.40 | 72.0 |
| 12 | Israel Abanikanda | Pittsburgh | SO | RB | 2 | 71 | 0 | 14 | 71 | 5.07 | 35.5 |
| 13 | Justice Ellison | Wk Forest | FR | RB | 2 | 64 | 0 | 13 | 64 | 4.92 | 32.0 |
| 14 | Will Shipley | Clemson | FR | RB | 1 | 61 | 0 | 18 | 61 | 3.39 | 61.0 |
| 15 | K.J. Cloyd | Louisville | SO | LB | 1 | 55 | 0 | 1 | 55 | 55.00 | 55.0 |
| 16 | Kobe Pace | Clemson | SO | RB | 1 | 51 | 0 | 12 | 51 | 4.25 | 51.0 |
| 17 | Nick Patti | Pittsburgh | JR | QB | 2 | 27 | 21 | 8 | 48 | 6.00 | 24.0 |
| 18 | Christian Beal-Smith | Wk Forest | JR | RB | 2 | 47 | 0 | 18 | 47 | 2.61 | 23.5 |
| 19 | Raheem Blackshear | Va Tech | JR | RB | 1 | 46 | 0 | 12 | 46 | 3.83 | 46.0 |
| 20 | Rodney Hammond Jr. | Pittsburgh | FR | RB | 2 | 42 | 0 | 10 | 42 | 4.20 | 21.0 |
| 21 | Tahj Bullock | Va Tech | FR | QB | 1 | 14 | 27 | 10 | 41 | 4.10 | 41.0 |
| 22 | Jawhar Jordan | Louisville | FR | RB | 1 | 37 | 0 | 6 | 37 | 6.17 | 37.0 |
| 23 | Jordan Addison | Pittsburgh | SO | WR | 2 | 33 | 0 | 2 | 33 | 16.50 | 16.5 |
| 24 | Ty Chandler | N Carolina | SR | RB | 1 | 29 | 0 | 9 | 29 | 3.22 | 29.0 |
| 25 | Drake Maye | N Carolina | FR | QB | 1 | 24 | 0 | 3 | 24 | 8.00 | 24.0 |
| 26 | Jalen Holston | Va Tech | JR | RB | 1 | 23 | 0 | 6 | 23 | 3.83 | 23.0 |
| 27 | Jared Wayne | Pittsburgh | JR | WR | 2 | 0 | 20 | 1 | 20 | 20.00 | 10.0 |
| 28 | Quinton Cooley | Wk Forest | FR | RB | 2 | 13 | 0 | 8 | 13 | 1.63 | 6.5 |
| 29 | Marco Lee | Va Tech | JR | RB | 1 | 12 | 0 | 2 | 12 | 6.00 | 12.0 |
| 30 | Peter Moore | Va Tech | FR | P | 1 | 8 | 0 | 1 | 8 | 8.00 | 8.0 |
| 31 | Phil Mafah | Clemson | FR | RB | 1 | 7 | 0 | 2 | 7 | 3.50 | 7.0 |
| 31 | Ahmani Marshall | Wk Forest | FR | RB | 1 | 7 | 0 | 3 | 7 | 2.33 | 7.0 |
| 31 | Malachi Thomas | Va Tech | FR | RB | 1 | 7 | 0 | 5 | 7 | 1.40 | 7.0 |
| 34 | Keshawn King | Va Tech | SO | RB | 1 | 1 | 0 | 1 | 1 | 1.00 | 1.0 |
| 34 | Taylor Morin | Wk Forest | FR | WR | 2 | 1 | 0 | 1 | 1 | 1.00 | 0.5 |