2021 Sun Belt Conference Leaders Total Defense - Games vs. Ranked Teams Only (AP Poll) through 01/10/2022
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | South Alabama | 1 | 225 | 58 | 54 | 283 | 5.24 | 283.0 |
| 2 | Troy | 1 | 204 | 166 | 67 | 370 | 5.52 | 370.0 |
| 3 | Georgia State | 1 | 143 | 287 | 71 | 430 | 6.06 | 430.0 |
| 4 | Arkansas State | 1 | 424 | 122 | 73 | 546 | 7.48 | 546.0 |
| 5 | Louisiana-Monroe | 2 | 310 | 636 | 129 | 946 | 7.33 | 473.0 |
| 6 | Texas State | 2 | 409 | 408 | 140 | 817 | 5.84 | 408.5 |
| 7 | Appalachian State | 2 | 434 | 419 | 142 | 853 | 6.01 | 426.5 |
| 8 | Georgia Southern | 3 | 594 | 924 | 207 | 1518 | 7.33 | 506.0 |