2021 Mountain West Conference Leaders Total Defense - Games vs. FBS Power 5 Conference Teams Only through 01/10/2022
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | San Diego State | 2 | 121 | 436 | 145 | 557 | 3.84 | 278.5 |
| 2 | New Mexico | 1 | 154 | 275 | 67 | 429 | 6.40 | 429.0 |
| 3 | Colorado State | 2 | 158 | 462 | 134 | 620 | 4.63 | 310.0 |
| 4 | San Jose State | 1 | 160 | 256 | 70 | 416 | 5.94 | 416.0 |
| 5 | Air Force | 1 | 232 | 194 | 64 | 426 | 6.66 | 426.0 |
| 6 | Boise State | 1 | 246 | 74 | 70 | 320 | 4.57 | 320.0 |
| 7 | Utah State | 2 | 301 | 465 | 127 | 766 | 6.03 | 383.0 |
| 8 | Fresno State | 2 | 303 | 450 | 126 | 753 | 5.98 | 376.5 |
| 9 | Nevada | 2 | 422 | 306 | 126 | 728 | 5.78 | 364.0 |
| 10 | UNLV | 2 | 474 | 484 | 143 | 958 | 6.70 | 479.0 |
| 11 | Hawai'i | 2 | 500 | 450 | 136 | 950 | 6.99 | 475.0 |