2021 Big 12 Conference Leaders Interceptions - Games vs. FBS Power 5 Conference Teams Only through 01/10/2022
| Name | G | Int. | Yards | TD | Int./G | |
|---|---|---|---|---|---|---|
| 1 | Baylor | 11 | 16 | 214 | 1 | 1.45 |
| 2 | Oklahoma | 11 | 10 | 67 | 0 | 0.91 |
| 3 | Kansas State | 11 | 9 | 82 | 0 | 0.82 |
| 4 | West Virginia | 12 | 9 | 104 | 0 | 0.75 |
| 5 | Iowa State | 11 | 8 | 58 | 1 | 0.73 |
| 6 | Oklahoma State | 10 | 7 | 148 | 1 | 0.70 |
| 6 | Kansas | 10 | 7 | 146 | 2 | 0.70 |
| 6 | Texas | 10 | 7 | 91 | 1 | 0.70 |
| 9 | TCU | 10 | 6 | 31 | 1 | 0.60 |
| 10 | Texas Tech | 10 | 5 | 15 | 0 | 0.50 |