2021 Big 12 Conference Leaders Passes Defended - Games vs. FBS (I-A) Teams Only through 01/10/2022
| Name | G | Int. | Passes Broken Up | Passes Defended | Passes Defended/G | |
|---|---|---|---|---|---|---|
| 1 | Texas Tech | 12 | 10 | 46 | 56 | 4.67 |
| 2 | Baylor | 13 | 19 | 44 | 63 | 4.85 |
| 2 | Oklahoma State | 13 | 9 | 44 | 53 | 4.08 |
| 4 | Texas | 12 | 7 | 31 | 38 | 3.17 |
| 5 | Iowa State | 12 | 9 | 29 | 38 | 3.17 |
| 6 | Kansas State | 12 | 10 | 26 | 36 | 3.00 |
| 7 | TCU | 11 | 9 | 25 | 34 | 3.09 |
| 7 | West Virginia | 12 | 9 | 25 | 34 | 2.83 |
| 9 | Oklahoma | 12 | 10 | 24 | 34 | 2.83 |
| 10 | Kansas | 11 | 7 | 19 | 26 | 2.36 |