2021 Big 12 Conference Leaders Passes Defended - Games vs. Ranked Teams Only (AP Poll) through 01/10/2022
| Name | G | Int. | Passes Broken Up | Passes Defended | Passes Defended/G | |
|---|---|---|---|---|---|---|
| 1 | Oklahoma State | 4 | 1 | 22 | 23 | 5.75 |
| 2 | Baylor | 5 | 12 | 18 | 30 | 6.00 |
| 3 | Texas Tech | 4 | 4 | 17 | 21 | 5.25 |
| 4 | Texas | 5 | 5 | 14 | 19 | 3.80 |
| 5 | West Virginia | 3 | 2 | 9 | 11 | 3.67 |
| 5 | Iowa State | 5 | 2 | 9 | 11 | 2.20 |
| 7 | Oklahoma | 3 | 4 | 8 | 12 | 4.00 |
| 8 | Kansas | 3 | 1 | 5 | 6 | 2.00 |
| 9 | TCU | 3 | 2 | 4 | 6 | 2.00 |
| 10 | Kansas State | 3 | 1 | 2 | 3 | 1.00 |