2021 Big 12 Conference Leaders First Downs - Games in December/January Only through 01/10/2022
| Name | G | Rush | Pass | Penalty | Total | Total/G | |
|---|---|---|---|---|---|---|---|
| 1 | Oklahoma State | 2 | 22 | 33 | 5 | 60 | 30.0 |
| 2 | Kansas State | 1 | 8 | 13 | 1 | 22 | 22.0 |
| 3 | Oklahoma | 1 | 13 | 12 | 2 | 27 | 27.0 |
| 4 | Texas Tech | 1 | 13 | 11 | 0 | 24 | 24.0 |
| 5 | Iowa State | 1 | 4 | 9 | 1 | 14 | 14.0 |
| 6 | Baylor | 2 | 17 | 8 | 2 | 27 | 13.5 |
| 7 | West Virginia | 1 | 7 | 7 | 1 | 15 | 15.0 |