2021 Big 12 Conference Leaders Rushing Offense - Games vs. Unranked Teams Only (AP Poll) through 01/10/2022
| Name | G | Att | Yards | Avg. | TD | Att/G | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Texas | 7 | 285 | 1715 | 6.02 | 16 | 40.71 | 245.00 |
| 2 | Baylor | 9 | 375 | 2028 | 5.41 | 20 | 41.67 | 225.33 |
| 3 | TCU | 9 | 369 | 1945 | 5.27 | 19 | 41.00 | 216.11 |
| 4 | Iowa State | 8 | 255 | 1602 | 6.28 | 20 | 31.88 | 200.25 |
| 5 | Oklahoma State | 10 | 441 | 1930 | 4.38 | 21 | 44.10 | 193.00 |
| 6 | Texas Tech | 9 | 322 | 1670 | 5.19 | 25 | 35.78 | 185.56 |
| 7 | Kansas State | 10 | 363 | 1844 | 5.08 | 28 | 36.30 | 184.40 |
| 8 | Oklahoma | 10 | 332 | 1833 | 5.52 | 24 | 33.20 | 183.30 |
| 9 | Kansas | 9 | 327 | 1298 | 3.97 | 13 | 36.33 | 144.22 |
| 10 | West Virginia | 10 | 352 | 1433 | 4.07 | 17 | 35.20 | 143.30 |