2021 Big 12 Conference Leaders Total Defense - Games vs. FBS (I-A) Teams Only through 01/10/2022
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Oklahoma State | 13 | 1125 | 2709 | 827 | 3834 | 4.64 | 294.9 |
| 2 | Baylor | 13 | 1491 | 3072 | 879 | 4563 | 5.19 | 351.0 |
| 3 | Iowa State | 12 | 1545 | 2205 | 738 | 3750 | 5.08 | 312.5 |
| 4 | Kansas State | 12 | 1586 | 2622 | 767 | 4208 | 5.49 | 350.7 |
| 5 | Oklahoma | 12 | 1622 | 3280 | 824 | 4902 | 5.95 | 408.5 |
| 6 | Texas Tech | 12 | 1755 | 3144 | 811 | 4899 | 6.04 | 408.3 |
| 7 | West Virginia | 12 | 1769 | 2690 | 769 | 4459 | 5.80 | 371.6 |
| 8 | Texas | 12 | 2419 | 2688 | 847 | 5107 | 6.03 | 425.6 |
| 9 | TCU | 11 | 2603 | 2801 | 727 | 5404 | 7.43 | 491.3 |
| 10 | Kansas | 11 | 2833 | 2739 | 746 | 5572 | 7.47 | 506.5 |