2021 Big 12 Conference Leaders Rushing Defense - Games vs. FBS (I-A) Teams Only through 01/10/2022
| Name | G | Att | Yards | Avg. | TD | Att/G | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Oklahoma State | 13 | 416 | 1125 | 2.70 | 9 | 32.00 | 86.54 |
| 2 | Baylor | 13 | 457 | 1491 | 3.26 | 15 | 35.15 | 114.69 |
| 3 | Iowa State | 12 | 423 | 1545 | 3.65 | 11 | 35.25 | 128.75 |
| 4 | Kansas State | 12 | 418 | 1586 | 3.79 | 12 | 34.83 | 132.17 |
| 5 | Oklahoma | 12 | 415 | 1622 | 3.91 | 15 | 34.58 | 135.17 |
| 6 | Texas Tech | 12 | 415 | 1755 | 4.23 | 18 | 34.58 | 146.25 |
| 7 | West Virginia | 12 | 422 | 1769 | 4.19 | 15 | 35.17 | 147.42 |
| 8 | Texas | 12 | 470 | 2419 | 5.15 | 26 | 39.17 | 201.58 |
| 9 | TCU | 11 | 431 | 2603 | 6.04 | 34 | 39.18 | 236.64 |
| 10 | Kansas | 11 | 454 | 2833 | 6.24 | 38 | 41.27 | 257.55 |