2021 Big 12 Conference Leaders Rushing Defense - Games Won Only through 01/10/2022
| Name | G | Att | Yards | Avg. | TD | Att/G | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Kansas | 2 | 73 | 329 | 4.51 | 3 | 36.50 | 164.50 |
| 2 | Texas Tech | 7 | 199 | 545 | 2.74 | 5 | 28.43 | 77.86 |
| 3 | TCU | 5 | 160 | 711 | 4.44 | 9 | 32.00 | 142.20 |
| 4 | Iowa State | 7 | 240 | 739 | 3.08 | 2 | 34.29 | 105.57 |
| 5 | Texas | 5 | 170 | 745 | 4.38 | 7 | 34.00 | 149.00 |
| 6 | West Virginia | 6 | 196 | 819 | 4.18 | 6 | 32.67 | 136.50 |
| 7 | Kansas State | 8 | 256 | 825 | 3.22 | 7 | 32.00 | 103.13 |
| 8 | Oklahoma State | 12 | 387 | 1098 | 2.84 | 8 | 32.25 | 91.50 |
| 9 | Oklahoma | 11 | 359 | 1240 | 3.45 | 10 | 32.64 | 112.73 |
| 10 | Baylor | 12 | 403 | 1339 | 3.32 | 13 | 33.58 | 111.58 |