2021 Big 12 Conference Leaders Opponent First Downs - Games in November Only through 01/10/2022
| Name | G | Rush | Pass | Penalty | Total | Total/G | |
|---|---|---|---|---|---|---|---|
| 1 | Iowa State | 4 | 36 | 28 | 3 | 67 | 16.8 |
| 2 | West Virginia | 4 | 29 | 30 | 4 | 63 | 15.8 |
| 2 | Kansas State | 4 | 32 | 41 | 4 | 77 | 19.3 |
| 4 | Texas | 4 | 34 | 46 | 6 | 86 | 21.5 |
| 4 | Kansas | 4 | 49 | 39 | 6 | 94 | 23.5 |
| 6 | TCU | 4 | 43 | 45 | 7 | 95 | 23.8 |
| 7 | Baylor | 4 | 21 | 43 | 8 | 72 | 18.0 |
| 7 | Texas Tech | 3 | 27 | 43 | 8 | 78 | 26.0 |
| 9 | Oklahoma State | 4 | 19 | 27 | 9 | 55 | 13.8 |
| 9 | Oklahoma | 3 | 28 | 33 | 9 | 70 | 23.3 |