2021 Big 12 Conference Leaders Opponent First Downs - Games vs. FBS Teams With Winning Record Only through 01/10/2022
| Name | G | Rush | Pass | Penalty | Total | Total/G | |
|---|---|---|---|---|---|---|---|
| 1 | West Virginia | 8 | 66 | 74 | 6 | 146 | 18.3 |
| 2 | Kansas State | 6 | 47 | 62 | 7 | 116 | 19.3 |
| 2 | Kansas | 7 | 94 | 73 | 7 | 174 | 24.9 |
| 4 | Iowa State | 7 | 54 | 59 | 8 | 121 | 17.3 |
| 5 | Texas | 8 | 78 | 85 | 10 | 173 | 21.6 |
| 6 | Texas Tech | 7 | 45 | 102 | 12 | 159 | 22.7 |
| 6 | TCU | 7 | 80 | 78 | 12 | 170 | 24.3 |
| 8 | Oklahoma | 6 | 57 | 69 | 14 | 140 | 23.3 |
| 9 | Baylor | 8 | 60 | 80 | 17 | 157 | 19.6 |
| 10 | Oklahoma State | 9 | 38 | 94 | 18 | 150 | 16.7 |