2021 Big 12 Conference Leaders Passing Defense - Games in November Only through 01/10/2022
| Name | G | Att | Comp | Pct. | Yards | Yards/Att | TD | Int | Rating | Att/G | Yards/G | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Oklahoma | 3 | 103 | 66 | 64.1 | 641 | 6.2 | 4 | 5 | 119.45 | 34.3 | 213.7 |
| 2 | TCU | 4 | 105 | 74 | 70.5 | 966 | 9.2 | 8 | 3 | 167.19 | 26.3 | 241.5 |
| 3 | Iowa State | 4 | 107 | 65 | 60.7 | 737 | 6.9 | 7 | 3 | 134.59 | 26.8 | 184.3 |
| 4 | West Virginia | 4 | 112 | 71 | 63.4 | 721 | 6.4 | 5 | 4 | 125.06 | 28.0 | 180.3 |
| 5 | Kansas | 4 | 114 | 81 | 71.1 | 1008 | 8.8 | 11 | 4 | 170.14 | 28.5 | 252.0 |
| 6 | Texas Tech | 3 | 115 | 71 | 61.7 | 849 | 7.4 | 6 | 2 | 137.50 | 38.3 | 283.0 |
| 7 | Oklahoma State | 4 | 116 | 58 | 50.0 | 653 | 5.6 | 3 | 1 | 104.09 | 29.0 | 163.3 |
| 8 | Baylor | 4 | 121 | 74 | 61.2 | 1073 | 8.9 | 4 | 3 | 141.60 | 30.3 | 268.3 |
| 9 | Texas | 4 | 127 | 86 | 67.7 | 869 | 6.8 | 7 | 0 | 143.39 | 31.8 | 217.3 |
| 10 | Kansas State | 4 | 133 | 89 | 66.9 | 839 | 6.3 | 5 | 3 | 127.80 | 33.3 | 209.8 |