2021 Big 12 Conference Leaders Opponent First Downs - Games in October Only through 01/10/2022
| Name | G | Rush | Pass | Penalty | Total | Total/G | |
|---|---|---|---|---|---|---|---|
| 1 | Oklahoma State | 4 | 17 | 27 | 6 | 50 | 12.5 |
| 2 | Kansas State | 4 | 29 | 38 | 4 | 71 | 17.8 |
| 3 | West Virginia | 4 | 30 | 43 | 3 | 76 | 19.0 |
| 3 | Baylor | 4 | 30 | 44 | 7 | 81 | 20.3 |
| 3 | Iowa State | 4 | 30 | 47 | 6 | 83 | 20.8 |
| 6 | Texas Tech | 5 | 38 | 60 | 3 | 101 | 20.2 |
| 6 | Oklahoma | 5 | 38 | 64 | 5 | 107 | 21.4 |
| 8 | Texas | 4 | 46 | 43 | 9 | 98 | 24.5 |
| 9 | Kansas | 4 | 53 | 40 | 3 | 96 | 24.0 |
| 10 | TCU | 5 | 54 | 51 | 11 | 116 | 23.2 |