2021 Big 12 Conference Leaders Total Defense - Games in August/September Only through 01/10/2022
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Iowa State | 4 | 275 | 583 | 222 | 858 | 3.86 | 214.5 |
| 2 | Baylor | 4 | 565 | 596 | 253 | 1161 | 4.59 | 290.3 |
| 3 | TCU | 3 | 544 | 630 | 175 | 1174 | 6.71 | 391.3 |
| 4 | West Virginia | 4 | 362 | 871 | 269 | 1233 | 4.58 | 308.3 |
| 5 | Oklahoma | 4 | 317 | 887 | 266 | 1204 | 4.53 | 301.0 |
| 6 | Oklahoma State | 4 | 348 | 898 | 275 | 1246 | 4.53 | 311.5 |
| 7 | Texas | 4 | 681 | 940 | 259 | 1621 | 6.26 | 405.3 |
| 7 | Kansas | 4 | 966 | 940 | 274 | 1906 | 6.96 | 476.5 |
| 9 | Texas Tech | 4 | 499 | 1011 | 294 | 1510 | 5.14 | 377.5 |
| 10 | Kansas State | 4 | 301 | 1020 | 261 | 1321 | 5.06 | 330.3 |