2021 Big 12 Conference Leaders Scoring Defense - Games in August/September Only through 01/10/2022
| Name | G | TD | FG | 1XP | 2XP | Safety | Points | Points/G | |
|---|---|---|---|---|---|---|---|---|---|
| 1 | TCU | 3 | 11 | 1 | 6 | 1 | 0 | 77 | 25.7 |
| 2 | Kansas | 4 | 22 | 2 | 22 | 0 | 0 | 160 | 40.0 |
| 3 | Oklahoma | 4 | 8 | 3 | 5 | 1 | 0 | 64 | 16.0 |
| 3 | Kansas State | 4 | 10 | 3 | 9 | 0 | 0 | 78 | 19.5 |
| 3 | Texas Tech | 4 | 18 | 3 | 17 | 0 | 0 | 134 | 33.5 |
| 6 | Baylor | 4 | 7 | 5 | 6 | 0 | 0 | 63 | 15.8 |
| 6 | Iowa State | 4 | 8 | 5 | 8 | 0 | 0 | 71 | 17.8 |
| 8 | West Virginia | 4 | 7 | 6 | 7 | 0 | 0 | 67 | 16.8 |
| 8 | Texas | 4 | 11 | 6 | 9 | 0 | 0 | 93 | 23.3 |
| 10 | Oklahoma State | 4 | 8 | 8 | 7 | 0 | 0 | 79 | 19.8 |