2021 Big 12 Conference Leaders Total Defense - Games vs. Conference Teams Only through 01/10/2022
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | West Virginia | 9 | 1250 | 2026 | 552 | 3276 | 5.93 | 364.0 |
| 2 | Iowa State | 9 | 1310 | 1818 | 555 | 3128 | 5.64 | 347.6 |
| 3 | TCU | 9 | 2120 | 2247 | 593 | 4367 | 7.36 | 485.2 |
| 4 | Oklahoma State | 10 | 899 | 1734 | 602 | 2633 | 4.37 | 263.3 |
| 5 | Kansas State | 9 | 1352 | 1984 | 603 | 3336 | 5.53 | 370.7 |
| 6 | Kansas | 9 | 2339 | 2166 | 604 | 4505 | 7.46 | 500.6 |
| 7 | Texas Tech | 9 | 1569 | 2489 | 607 | 4058 | 6.69 | 450.9 |
| 8 | Oklahoma | 9 | 1236 | 2389 | 611 | 3625 | 5.93 | 402.8 |
| 9 | Texas | 9 | 1866 | 2140 | 656 | 4006 | 6.11 | 445.1 |
| 10 | Baylor | 10 | 1207 | 2390 | 669 | 3597 | 5.38 | 359.7 |