2021 Big 12 Conference Leaders Rushing - Games vs. FBS non-Power 5 Conference Teams Only through 01/10/2022
| Name | Team | Yr | Pos | G | Att | Yards | Avg. | TD | Att/G | Yards/G | |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Abram Smith | Baylor | SR | RB | 2 | 46 | 306 | 6.65 | 5 | 23.00 | 153.00 |
| 2 | Bijan Robinson | Texas | SO | RB | 2 | 33 | 230 | 6.97 | 4 | 16.50 | 115.00 |
| 3 | Jaylen Warren | Okla St | SR | RB | 3 | 65 | 337 | 5.18 | 3 | 21.67 | 112.33 |
| 4 | Jason Bean | Kansas | JR | QB | 1 | 13 | 100 | 7.69 | 2 | 13.00 | 100.00 |
| 4 | Breece Hall | Iowa State | JR | RB | 1 | 21 | 100 | 4.76 | 2 | 21.00 | 100.00 |
| 4 | Tahj Brooks | Texas Tech | SO | RB | 2 | 24 | 181 | 7.54 | 2 | 12.00 | 90.50 |
| 4 | Will Howard | Kansas St | SO | QB | 1 | 12 | 56 | 4.67 | 2 | 12.00 | 56.00 |
| 8 | Deuce Vaughn | Kansas St | SO | RB | 1 | 23 | 127 | 5.52 | 1 | 23.00 | 127.00 |
| 8 | Kennedy Brooks | Oklahoma | JR | RB | 1 | 14 | 87 | 6.21 | 1 | 14.00 | 87.00 |
| 8 | Joe Ervin | Kansas St | SO | RB | 1 | 11 | 82 | 7.45 | 1 | 11.00 | 82.00 |
| 8 | Spencer Sanders | Okla St | JR | QB | 3 | 42 | 227 | 5.40 | 1 | 14.00 | 75.67 |
| 8 | Roschon Johnson | Texas | JR | RB | 2 | 11 | 139 | 12.64 | 1 | 5.50 | 69.50 |
| 8 | Jonathon Brooks | Texas | FR | RB | 1 | 9 | 63 | 7.00 | 1 | 9.00 | 63.00 |
| 8 | Keilan Robinson | Texas | JR | RB | 2 | 13 | 124 | 9.54 | 1 | 6.50 | 62.00 |
| 8 | Devin Neal | Kansas | FR | RB | 1 | 11 | 40 | 3.64 | 1 | 11.00 | 40.00 |
| 8 | Deon Silas | Iowa State | FR | RB | 1 | 5 | 32 | 6.40 | 1 | 5.00 | 32.00 |
| 8 | Kendre Miller | TCU | SO | RB | 1 | 5 | 27 | 5.40 | 1 | 5.00 | 27.00 |
| 8 | Henry Colombi | Texas Tech | SR | QB | 1 | 2 | 22 | 11.00 | 1 | 2.00 | 22.00 |
| 8 | SaRodorick Thompson | Texas Tech | JR | RB | 1 | 4 | 11 | 2.75 | 1 | 4.00 | 11.00 |
| 8 | Spencer Rattler | Oklahoma | SO | QB | 1 | 8 | 7 | 0.88 | 1 | 8.00 | 7.00 |
| 8 | Dillon Doyle | Baylor | JR | LB | 2 | 1 | 2 | 2.00 | 1 | 0.50 | 1.00 |
| 8 | Caleb Williams | Oklahoma | FR | QB | 1 | 1 | 1 | 1.00 | 1 | 1.00 | 1.00 |
| 8 | Tyler Shough | Texas Tech | JR | QB | 2 | 9 | 2 | 0.22 | 1 | 4.50 | 1.00 |
| 8 | Hudson Card | Texas | FR | QB | 2 | 7 | 1 | 0.14 | 1 | 3.50 | 0.50 |