2021 Big 12 Conference Leaders Sacks - Games in November Only through 01/10/2022
| Name | Team | Yr | Pos | G | Sacks | Sack Yards | Sacks/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Gabe Hall | Baylor | SO | DL | 4 | 5.0 | 21 | 1.25 |
| 2 | Will McDonald IV | Iowa State | JR | DE | 4 | 4.0 | 26 | 1.00 |
| 2 | Collin Oliver | Okla St | FR | DE | 4 | 4.0 | 22 | 1.00 |
| 4 | Eyioma Uwazurike | Iowa State | SR | DE | 4 | 3.5 | 36 | 0.88 |
| 4 | Brock Martin | Okla St | SR | DE | 4 | 3.5 | 21 | 0.88 |
| 4 | Devin Harper | Okla St | SR | LB | 4 | 3.5 | 18 | 0.88 |
| 7 | Malcolm Rodriguez | Okla St | SR | LB | 4 | 3.0 | 20 | 0.75 |
| 7 | Kyron Johnson | Kansas | SR | DE | 4 | 3.0 | 15 | 0.75 |
| 9 | Isaiah Thomas | Oklahoma | SR | DL | 3 | 2.5 | 17 | 0.83 |
| 10 | Nate Matlack | Kansas St | FR | DE | 4 | 2.0 | 21 | 0.50 |
| 10 | Akheem Mesidor | WVU | SO | DL | 4 | 2.0 | 21 | 0.50 |
| 10 | Blake Peterson | Iowa State | SO | DE | 4 | 2.0 | 20 | 0.50 |
| 10 | Tyler Lacy | Okla St | JR | DE | 4 | 2.0 | 17 | 0.50 |
| 10 | Dylan Horton | TCU | SR | DE | 4 | 2.0 | 16 | 0.50 |
| 10 | Nik Bonitto | Oklahoma | JR | OLB | 3 | 2.0 | 13 | 0.67 |
| 10 | Terrel Bernard | Baylor | SR | LB | 4 | 2.0 | 13 | 0.50 |
| 10 | Eli Huggins | Kansas St | SR | DT | 4 | 2.0 | 10 | 0.50 |
| 10 | Daniel Green | Kansas St | JR | LB | 4 | 2.0 | 10 | 0.50 |
| 10 | Kolby Harvell-Peel | Okla St | SR | S | 4 | 2.0 | 7 | 0.50 |
| 10 | Mike Rose | Iowa State | SR | LB | 4 | 2.0 | 6 | 0.50 |
| 21 | Jason Taylor II | Okla St | JR | S | 4 | 1.5 | 30 | 0.38 |
| 21 | Tony Bradford Jr. | Texas Tech | JR | DL | 3 | 1.5 | 5 | 0.50 |
| 21 | Israel Antwine | Okla St | SR | DT | 4 | 1.5 | 5 | 0.38 |
| 21 | Kamryn Farrar | Okla St | SO | LB | 4 | 1.5 | 4 | 0.38 |
| 21 | David Gbenda | Texas | SO | LB | 4 | 1.5 | 3 | 0.38 |
| 26 | Malcolm Lee | Kansas | SR | DL | 4 | 1.0 | 20 | 0.25 |
| 26 | Key Lawrence | Oklahoma | SO | DB | 3 | 1.0 | 18 | 0.33 |
| 26 | Ben Davis | Texas | SR | EDG | 4 | 1.0 | 16 | 0.25 |
| 26 | Rich Miller | Kansas | JR | LB | 4 | 1.0 | 14 | 0.25 |
| 26 | Matt Jones | Baylor | SO | LB | 4 | 1.0 | 11 | 0.25 |
| 26 | Jarrick Bernard-Converse | Okla St | SR | CB | 4 | 1.0 | 11 | 0.25 |
| 26 | Raleigh Texada | Baylor | SR | CB | 4 | 1.0 | 10 | 0.25 |
| 26 | Josh Landry | Baylor | JR | DT | 4 | 1.0 | 10 | 0.25 |
| 26 | Nook Bradford | TCU | JR | S | 4 | 1.0 | 9 | 0.25 |
| 26 | Brian Asamoah | Oklahoma | JR | LB | 3 | 1.0 | 8 | 0.33 |
| 26 | Isaiah Lee | Iowa State | JR | DT | 4 | 1.0 | 7 | 0.25 |
| 26 | Zion DeBose | Kansas | SR | DE | 4 | 1.0 | 7 | 0.25 |
| 26 | Nate Betts | Kansas | SR | LB | 4 | 1.0 | 7 | 0.25 |
| 26 | Kody Walterscheid | Okla St | SO | DE | 4 | 1.0 | 7 | 0.25 |
| 26 | Perrion Winfrey | Oklahoma | SR | DL | 3 | 1.0 | 6 | 0.33 |
| 26 | Jalen Redmond | Oklahoma | SO | DL | 3 | 1.0 | 6 | 0.33 |
| 26 | Brayden Utley | Baylor | JR | DL | 4 | 1.0 | 5 | 0.25 |
| 26 | Felix Anudike-Uzomah | Kansas St | SO | DE | 4 | 1.0 | 4 | 0.25 |
| 26 | Timmy Horne | Kansas St | SR | DT | 4 | 1.0 | 4 | 0.25 |
| 26 | Brendon Evers | Okla St | SR | DT | 4 | 1.0 | 4 | 0.25 |
| 26 | T'Vondre Sweat | Texas | JR | DL | 4 | 1.0 | 4 | 0.25 |
| 26 | Jereme Robinson | Kansas | SO | DL | 2 | 1.0 | 2 | 0.50 |
| 26 | Tucker Robertson | Iowa State | SR | DL | 4 | 1.0 | 2 | 0.25 |
| 26 | TJ Franklin | Baylor | JR | DL | 4 | 1.0 | 1 | 0.25 |
| 26 | Anthony Johnson Jr. | Iowa State | SR | DB | 4 | 1.0 | 1 | 0.25 |