2021 Big 12 Conference Leaders Sacks - Games in August/September Only through 01/10/2022
| Name | Team | Yr | Pos | G | Sacks | Sack Yards | Sacks/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Felix Anudike-Uzomah | Kansas St | SO | DE | 4 | 4.0 | 16 | 1.00 |
| 2 | Will McDonald IV | Iowa State | JR | DE | 4 | 3.5 | 27 | 0.88 |
| 2 | Taijh Alston | WVU | JR | DL | 4 | 3.5 | 21 | 0.88 |
| 2 | Perrion Winfrey | Oklahoma | SR | DL | 4 | 3.5 | 19 | 0.88 |
| 5 | Eyioma Uwazurike | Iowa State | SR | DE | 4 | 3.0 | 19 | 0.75 |
| 5 | Jared Bartlett | WVU | SO | BAN | 4 | 3.0 | 19 | 0.75 |
| 7 | Isaiah Thomas | Oklahoma | SR | DL | 4 | 2.5 | 21 | 0.63 |
| 7 | Brock Martin | Okla St | SR | DE | 4 | 2.5 | 19 | 0.63 |
| 7 | Nik Bonitto | Oklahoma | JR | OLB | 4 | 2.5 | 7 | 0.63 |
| 10 | Tyree Wilson | Texas Tech | JR | DL | 4 | 2.0 | 18 | 0.50 |
| 10 | Khalid Duke | Kansas St | JR | DE | 3 | 2.0 | 17 | 0.67 |
| 10 | Jaylon Hutchings | Texas Tech | JR | DL | 4 | 2.0 | 17 | 0.50 |
| 10 | Dante Stills | WVU | SR | DL | 4 | 2.0 | 17 | 0.50 |
| 10 | Ovie Oghoufo | Texas | JR | EDG | 4 | 2.0 | 7 | 0.50 |
| 15 | Reggie Grimes | Oklahoma | SO | DE | 4 | 1.5 | 18 | 0.38 |
| 15 | Tyler Lacy | Okla St | JR | DE | 4 | 1.5 | 15 | 0.38 |
| 15 | Devin Harper | Okla St | SR | LB | 4 | 1.5 | 15 | 0.38 |
| 15 | Jalen Redmond | Oklahoma | SO | DL | 3 | 1.5 | 9 | 0.50 |
| 15 | Kyron Johnson | Kansas | SR | DE | 4 | 1.5 | 7 | 0.38 |
| 20 | Jacob Morgenstern | Texas Tech | SR | LB | 4 | 1.0 | 15 | 0.25 |
| 20 | Ashton Logan | Baylor | SR | OLB | 4 | 1.0 | 13 | 0.25 |
| 20 | Jake Hummel | Iowa State | SR | LB | 4 | 1.0 | 11 | 0.25 |
| 20 | Akheem Mesidor | WVU | SO | DL | 4 | 1.0 | 10 | 0.25 |
| 20 | Reggie Stubblefield | Kansas St | SR | DB | 3 | 1.0 | 9 | 0.33 |
| 20 | Dee Winters | TCU | JR | LB | 3 | 1.0 | 9 | 0.33 |
| 20 | Jett Bush | Texas | JR | LB | 3 | 1.0 | 9 | 0.33 |
| 20 | Ben Kopenski | Okla St | JR | DE | 4 | 1.0 | 9 | 0.25 |
| 20 | Terrel Bernard | Baylor | SR | LB | 4 | 1.0 | 8 | 0.25 |
| 20 | Alfred Collins | Texas | SO | DL | 4 | 1.0 | 8 | 0.25 |
| 20 | O'Rien Vance | Iowa State | SR | LB | 2 | 1.0 | 7 | 0.50 |
| 20 | Lamont Bishop | Okla St | JR | LB | 3 | 1.0 | 7 | 0.33 |
| 20 | Ochaun Mathis | TCU | JR | DE | 3 | 1.0 | 7 | 0.33 |
| 20 | Cody Fletcher | Kansas St | SR | LB | 4 | 1.0 | 7 | 0.25 |
| 20 | Jahron McPherson | Kansas St | SR | DB | 4 | 1.0 | 7 | 0.25 |
| 20 | Mason Cobb | Okla St | SO | LB | 4 | 1.0 | 7 | 0.25 |
| 20 | Tony Bradford Jr. | Texas Tech | JR | DL | 4 | 1.0 | 7 | 0.25 |
| 20 | Matt Jones | Baylor | SO | LB | 4 | 1.0 | 6 | 0.25 |
| 20 | Eli Huggins | Kansas St | SR | DT | 4 | 1.0 | 6 | 0.25 |
| 20 | Jayden Jernigan | Okla St | SO | DT | 4 | 1.0 | 6 | 0.25 |
| 20 | Ray Thornton | Texas | SR | EDG | 4 | 1.0 | 6 | 0.25 |
| 20 | Alonzo Addae | WVU | SR | S | 4 | 1.0 | 6 | 0.25 |
| 20 | Daniel Green | Kansas St | JR | LB | 4 | 1.0 | 5 | 0.25 |
| 20 | Kamryn Farrar | Okla St | SO | LB | 4 | 1.0 | 5 | 0.25 |
| 20 | Josh Ellison | Oklahoma | JR | DL | 4 | 1.0 | 5 | 0.25 |
| 20 | Krishon Merriweather | Texas Tech | SR | LB | 4 | 1.0 | 5 | 0.25 |
| 20 | Byron Murphy II | Texas | FR | DL | 4 | 1.0 | 5 | 0.25 |
| 20 | Gerry Vaughn | Iowa State | JR | LB | 4 | 1.0 | 4 | 0.25 |
| 20 | Israel Antwine | Okla St | SR | DT | 3 | 1.0 | 3 | 0.33 |
| 20 | La'Kendrick Van Zandt | TCU | SR | S | 3 | 1.0 | 3 | 0.33 |
| 20 | Mike Rose | Iowa State | SR | LB | 4 | 1.0 | 3 | 0.25 |