2021 Big 12 Conference Leaders Long All Purpose Plays - Games in October Only through 01/10/2022
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| Name | Team | Yr | Pos | G | Yards | Yards | Yards | Yards | Yards | Yards | Yards | |
| 1 | Breece Hall | Iowa State | JR | RB | 4 | 6 | 4 | 3 | 2 | 2 | 0 | 0 |
| 1 | Kendre Miller | TCU | SO | RB | 5 | 5 | 4 | 3 | 2 | 1 | 0 | 0 |
| 1 | Xavier Worthy | Texas | FR | WR | 4 | 5 | 3 | 2 | 2 | 1 | 0 | 0 |
| 4 | Nik Bonitto | Oklahoma | JR | OLB | 5 | 1 | 1 | 1 | 1 | 1 | 0 | 0 |
| 4 | Kennedy Brooks | Oklahoma | JR | RB | 5 | 4 | 2 | 1 | 1 | 0 | 0 | 0 |
| 4 | Derius Davis | TCU | SR | WR | 5 | 5 | 2 | 1 | 1 | 1 | 1 | 1 |
| 4 | Garrett Greene | WVU | FR | QB | 4 | 1 | 1 | 1 | 1 | 0 | 0 | 0 |
| 4 | Daniel Imatorbhebhe | Kansas St | SR | TE | 4 | 2 | 1 | 1 | 1 | 1 | 0 | 0 |
| 4 | Quentin Johnston | TCU | SO | WR | 4 | 3 | 2 | 1 | 1 | 1 | 0 | 0 |
| 4 | Malik Knowles | Kansas St | JR | WR | 4 | 3 | 1 | 1 | 1 | 1 | 1 | 1 |
| 4 | Tarique Milton | Iowa State | SR | WR | 4 | 2 | 1 | 1 | 1 | 0 | 0 | 0 |
| 4 | Marvin Mims | Oklahoma | SO | WR | 5 | 6 | 6 | 2 | 1 | 0 | 0 | 0 |
| 4 | JD Spielman | TCU | SR | WR | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 |
| 4 | Jason Taylor II | Okla St | JR | S | 4 | 1 | 1 | 1 | 1 | 1 | 1 | 0 |
| 4 | SaRodorick Thompson | Texas Tech | JR | RB | 5 | 1 | 1 | 1 | 1 | 1 | 0 | 0 |
| 4 | Tyquan Thornton | Baylor | SR | WR | 4 | 4 | 4 | 1 | 1 | 1 | 0 | 0 |
| 4 | Trevon West | Oklahoma | SO | WR | 5 | 2 | 1 | 1 | 1 | 0 | 0 | 0 |
| 4 | Caleb Williams | Oklahoma | FR | QB | 5 | 3 | 3 | 1 | 1 | 0 | 0 | 0 |