2021 Big 12 Conference Leaders Tackles For Loss - Games in October Only through 01/10/2022
| Name | Team | Yr | Pos | G | TFL | TFL Yards | TFL/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Felix Anudike-Uzomah | Kansas St | SO | DE | 4 | 7.5 | 35 | 1.88 |
| 1 | Dante Stills | WVU | SR | DL | 4 | 7.5 | 35 | 1.88 |
| 3 | Tyree Wilson | Texas Tech | JR | DL | 5 | 6.0 | 29 | 1.20 |
| 4 | Isaiah Thomas | Oklahoma | SR | DL | 5 | 6.5 | 28 | 1.30 |
| 5 | Nik Bonitto | Oklahoma | JR | OLB | 5 | 5.5 | 27 | 1.10 |
| 5 | Ochaun Mathis | TCU | JR | DE | 5 | 5.0 | 27 | 1.00 |
| 7 | Collin Oliver | Okla St | FR | DE | 4 | 6.0 | 24 | 1.50 |
| 7 | Jalen Pitre | Baylor | SR | S | 4 | 4.0 | 24 | 1.00 |
| 7 | Will McDonald IV | Iowa State | JR | DE | 4 | 4.0 | 24 | 1.00 |
| 7 | Dylan Horton | TCU | SR | DE | 5 | 3.0 | 24 | 0.60 |
| 11 | Siaki Ika | Baylor | SO | DT | 4 | 3.5 | 23 | 0.88 |
| 12 | Eyioma Uwazurike | Iowa State | SR | DE | 4 | 3.5 | 21 | 0.88 |
| 12 | Anthony Cook | Texas | SR | DB | 4 | 3.0 | 21 | 0.75 |
| 14 | Taijh Alston | WVU | JR | DL | 4 | 3.5 | 18 | 0.88 |
| 14 | Josh Chandler-Semedo | WVU | SR | LB | 4 | 3.5 | 18 | 0.88 |
| 14 | TJ Franklin | Baylor | JR | DL | 4 | 2.0 | 18 | 0.50 |
| 17 | Daniel Green | Kansas St | JR | LB | 4 | 4.0 | 17 | 1.00 |
| 18 | Terrel Bernard | Baylor | SR | LB | 3 | 2.5 | 16 | 0.83 |
| 19 | Akheem Mesidor | WVU | SO | DL | 4 | 2.5 | 15 | 0.63 |
| 20 | Dillon Doyle | Baylor | JR | LB | 4 | 3.5 | 14 | 0.88 |
| 20 | Kyron Johnson | Kansas | SR | DE | 4 | 3.0 | 14 | 0.75 |
| 20 | Devin Harper | Okla St | SR | LB | 4 | 2.0 | 14 | 0.50 |
| 23 | Caleb Sampson | Kansas | SR | DL | 4 | 1.5 | 13 | 0.38 |
| 24 | Alfred Collins | Texas | SO | DL | 4 | 3.0 | 12 | 0.75 |
| 25 | DeMarvion Overshown | Texas | SR | LB | 4 | 2.5 | 11 | 0.63 |
| 25 | Colin Schooler | Texas Tech | SR | LB | 5 | 2.0 | 11 | 0.40 |
| 27 | Ray Thornton | Texas | SR | EDG | 4 | 3.0 | 10 | 0.75 |
| 27 | Jaylon Hutchings | Texas Tech | JR | DL | 5 | 1.5 | 10 | 0.30 |
| 27 | Victor Obi | Baylor | JR | OLB | 1 | 1.0 | 10 | 1.00 |
| 30 | Timmy Horne | Kansas St | SR | DT | 4 | 2.0 | 9 | 0.50 |
| 31 | Malcolm Rodriguez | Okla St | SR | LB | 4 | 4.5 | 8 | 1.13 |
| 31 | Perrion Winfrey | Oklahoma | SR | DL | 5 | 2.5 | 8 | 0.50 |
| 31 | Key Lawrence | Oklahoma | SO | DB | 5 | 2.5 | 8 | 0.50 |
| 31 | Justin Broiles | Oklahoma | SR | DB | 5 | 2.0 | 8 | 0.40 |
| 31 | Jamoi Hodge | TCU | SO | LB | 5 | 1.0 | 8 | 0.20 |
| 36 | Corey Bethley | TCU | SR | DT | 3 | 1.0 | 7 | 0.33 |
| 36 | Jayden Jernigan | Okla St | SO | DT | 4 | 1.0 | 7 | 0.25 |
| 36 | Brendon Evers | Okla St | SR | DT | 4 | 1.0 | 7 | 0.25 |
| 36 | Keondre Coburn | Texas | JR | DL | 4 | 1.0 | 7 | 0.25 |
| 36 | Khari Coleman | TCU | SO | DE | 5 | 1.0 | 7 | 0.20 |
| 41 | Matt Jones | Baylor | SO | LB | 4 | 2.0 | 6 | 0.50 |
| 41 | Reggie Stubblefield | Kansas St | SR | DB | 4 | 2.0 | 6 | 0.50 |
| 41 | Jason Taylor II | Okla St | JR | S | 4 | 1.5 | 6 | 0.38 |
| 41 | Bryson Jackson | Baylor | SR | OLB | 4 | 1.0 | 6 | 0.25 |
| 41 | Nate Matlack | Kansas St | FR | DE | 4 | 1.0 | 6 | 0.25 |
| 46 | Tyren Irby | Okla St | SR | DE | 1 | 2.0 | 5 | 2.00 |
| 46 | La'Kendrick Van Zandt | TCU | SR | S | 5 | 1.5 | 5 | 0.30 |
| 46 | Brayden Utley | Baylor | JR | DL | 4 | 1.0 | 5 | 0.25 |
| 46 | Spencer Trussell | Kansas St | JR | DE | 4 | 1.0 | 5 | 0.25 |
| 46 | B.J. Foster | Texas | SR | DB | 4 | 1.0 | 5 | 0.25 |