2021 Big 12 Conference Leaders Passes Defended - Games vs. Unranked Teams Only (AP Poll) through 01/10/2022
| Name | Team | Yr | Pos | G | Int. | Passes Broken Up | Passes Defended | Passes Defended/G | |
|---|---|---|---|---|---|---|---|---|---|
| 1 | Russ Yeast | Kansas St | SR | DB | 10 | 4 | 9 | 13 | 1.30 |
| 2 | Dadrion Taylor-Demerson | Texas Tech | JR | DB | 9 | 3 | 8 | 11 | 1.22 |
| 2 | Kolby Harvell-Peel | Okla St | SR | S | 10 | 3 | 1 | 4 | 0.40 |
| 4 | Jalen Pitre | Baylor | SR | S | 9 | 2 | 5 | 7 | 0.78 |
| 4 | Tre'Vius Hodges-Tomlinson | TCU | JR | CB | 9 | 2 | 5 | 7 | 0.78 |
| 4 | Charles Woods | WVU | JR | CB | 8 | 2 | 3 | 5 | 0.63 |
| 4 | Isheem Young | Iowa State | SO | DB | 8 | 2 | 2 | 4 | 0.50 |
| 4 | Dee Winters | TCU | JR | LB | 9 | 2 | 2 | 4 | 0.44 |
| 4 | TJ Smith | Kansas St | FR | DB | 10 | 2 | 2 | 4 | 0.40 |
| 4 | Jason Taylor II | Okla St | JR | S | 10 | 2 | 2 | 4 | 0.40 |
| 4 | Sean Mahone | WVU | SR | S | 10 | 2 | 2 | 4 | 0.40 |
| 4 | Delarrin Turner-Yell | Oklahoma | SR | S | 7 | 2 | 1 | 3 | 0.43 |
| 4 | Greg Eisworth II | Iowa State | SR | DB | 8 | 2 | 1 | 3 | 0.38 |
| 4 | JT Woods | Baylor | SR | S | 9 | 2 | 1 | 3 | 0.33 |
| 4 | Jacobee Bryant | Kansas | FR | CB | 9 | 2 | 1 | 3 | 0.33 |
| 4 | Patrick Fields | Oklahoma | SR | S | 10 | 2 | 1 | 3 | 0.30 |
| 4 | Josh Chandler-Semedo | WVU | SR | LB | 10 | 2 | 1 | 3 | 0.30 |
| 18 | Kenny Logan Jr. | Kansas | JR | S | 9 | 1 | 5 | 6 | 0.67 |
| 18 | Christian Holmes | Okla St | SR | CB | 10 | 1 | 5 | 6 | 0.60 |
| 18 | Ross Elder | Kansas St | SR | DB | 10 | 1 | 4 | 5 | 0.50 |
| 18 | Daryl Porter Jr. | WVU | FR | CB | 10 | 1 | 4 | 5 | 0.50 |
| 18 | Al Walcott | Baylor | JR | CB | 7 | 1 | 3 | 4 | 0.57 |
| 18 | Eric Monroe | Texas Tech | SR | DB | 9 | 1 | 3 | 4 | 0.44 |
| 18 | Tanner McCalister | Okla St | SR | S | 10 | 1 | 3 | 4 | 0.40 |
| 18 | Datrone Young | Iowa State | SR | DB | 7 | 1 | 2 | 3 | 0.43 |
| 18 | Jake Hummel | Iowa State | SR | LB | 8 | 1 | 2 | 3 | 0.38 |
| 18 | O.J. Burroughs | Kansas | FR | S | 9 | 1 | 2 | 3 | 0.33 |
| 18 | Colin Schooler | Texas Tech | SR | LB | 9 | 1 | 2 | 3 | 0.33 |
| 18 | Josh Thompson | Texas | SR | DB | 4 | 1 | 1 | 2 | 0.50 |
| 18 | Kym-Mani King | Iowa State | JR | DB | 7 | 1 | 1 | 2 | 0.29 |
| 18 | T.J. Carter | TCU | SR | S | 7 | 1 | 1 | 2 | 0.29 |
| 18 | Wyatt Harris | TCU | JR | LB | 7 | 1 | 1 | 2 | 0.29 |
| 18 | Jairon McVea | Baylor | SR | S | 8 | 1 | 1 | 2 | 0.25 |
| 18 | Nook Bradford | TCU | JR | S | 8 | 1 | 1 | 2 | 0.25 |
| 18 | Ra'Mello Dotson | Kansas | FR | CB | 9 | 1 | 1 | 2 | 0.22 |
| 18 | D.J. Graham | Oklahoma | SO | CB | 9 | 1 | 1 | 2 | 0.22 |
| 18 | Justin Broiles | Oklahoma | SR | DB | 10 | 1 | 1 | 2 | 0.20 |
| 18 | Deshawn McCuin | TCU | SO | S | 2 | 1 | 0 | 1 | 0.50 |
| 18 | Marquis Waters | Texas Tech | SR | DB | 3 | 1 | 0 | 1 | 0.33 |
| 18 | Nick Session | Okla St | FR | S | 4 | 1 | 0 | 1 | 0.25 |
| 18 | Garmon Randolph | Baylor | SO | OLB | 6 | 1 | 0 | 1 | 0.17 |
| 18 | Luke Brockermeyer | Texas | JR | LB | 6 | 1 | 0 | 1 | 0.17 |
| 18 | Craig McDonald | Iowa State | FR | DB | 8 | 1 | 0 | 1 | 0.13 |
| 18 | Aric Horne | Iowa State | SO | LB | 8 | 1 | 0 | 1 | 0.13 |
| 18 | Bryson Washington | Oklahoma | FR | S | 8 | 1 | 0 | 1 | 0.13 |
| 18 | Tee Denson | Kansas St | SO | DB | 9 | 1 | 0 | 1 | 0.11 |
| 18 | Gavin Potter | Kansas | JR | LB | 9 | 1 | 0 | 1 | 0.11 |
| 18 | Cody Fletcher | Kansas St | SR | LB | 10 | 1 | 0 | 1 | 0.10 |
| 18 | Jaylen Pickle | Kansas St | JR | DT | 10 | 1 | 0 | 1 | 0.10 |