2021 Big 12 Conference Leaders Long Rushing Plays - Games Lost Only through 01/10/2022
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| Name | Team | Yr | Pos | G | Yards | Yards | Yards | Yards | Yards | Yards | Yards | Yards | Yards | |
| 1 | Devin Neal | Kansas | FR | RB | 9 | 12 | 3 | 2 | 2 | 1 | 1 | 0 | 0 | 0 |
| 2 | Breece Hall | Iowa State | JR | RB | 5 | 11 | 6 | 5 | 3 | 2 | 1 | 1 | 0 | 0 |
| 2 | Bijan Robinson | Texas | SO | RB | 6 | 11 | 5 | 3 | 1 | 1 | 0 | 0 | 0 | 0 |
| 2 | Deuce Vaughn | Kansas St | SO | RB | 5 | 11 | 4 | 1 | 1 | 1 | 1 | 0 | 0 | 0 |
| 5 | Jason Bean | Kansas | JR | QB | 10 | 10 | 4 | 2 | 1 | 0 | 0 | 0 | 0 | 0 |
| 6 | Leddie Brown | WVU | SR | RB | 6 | 9 | 3 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| 6 | Max Duggan | TCU | JR | QB | 6 | 9 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| 8 | Emari Demercado | TCU | SR | RB | 7 | 7 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
| 9 | Zach Evans | TCU | SO | RB | 3 | 6 | 3 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
| 9 | Garrett Greene | WVU | FR | QB | 5 | 6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| 9 | SaRodorick Thompson | Texas Tech | JR | RB | 6 | 6 | 3 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| 12 | Kennedy Brooks | Oklahoma | JR | RB | 2 | 5 | 2 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
| 12 | Brock Purdy | Iowa State | SR | QB | 6 | 5 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| 14 | Kendre Miller | TCU | SO | RB | 5 | 4 | 4 | 1 | 1 | 1 | 1 | 0 | 0 | 0 |
| 14 | Amauri Pesek-Hickson | Kansas | FR | RB | 9 | 4 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| 14 | Abram Smith | Baylor | SR | RB | 2 | 4 | 3 | 2 | 2 | 1 | 0 | 0 | 0 | 0 |
| 14 | Casey Thompson | Texas | JR | QB | 7 | 4 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| 18 | Tahj Brooks | Texas Tech | SO | RB | 4 | 3 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| 18 | Jalon Daniels | Kansas | SO | QB | 5 | 3 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| 18 | Joe Ervin | Kansas St | SO | RB | 4 | 3 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| 18 | Erik Ezukanma | Texas Tech | JR | WR | 6 | 3 | 2 | 1 | 1 | 0 | 0 | 0 | 0 | 0 |
| 18 | Kaylon Geiger Sr. | Texas Tech | SR | WR | 6 | 3 | 2 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
| 18 | Miles Kendrick | Kansas | SR | QB | 5 | 3 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| 18 | Tony Mathis Jr. | WVU | SO | RB | 5 | 3 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| 18 | Spencer Sanders | Okla St | JR | QB | 2 | 3 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| 18 | Jaylen Warren | Okla St | SR | RB | 2 | 3 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| 18 | Ahmonte Watkins | TCU | FR | RB | 2 | 3 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| 18 | Caleb Williams | Oklahoma | FR | QB | 2 | 3 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 |
| 29 | Jirehl Brock | Iowa State | SO | RB | 6 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| 29 | Henry Colombi | Texas Tech | SR | QB | 4 | 2 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| 29 | Jarret Doege | WVU | SR | QB | 7 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| 29 | Velton Gardner | Kansas | JR | RB | 2 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| 29 | Will Howard | Kansas St | SO | QB | 2 | 2 | 2 | 2 | 1 | 1 | 1 | 1 | 0 | 0 |
| 29 | Dezmon Jackson | Okla St | SR | RB | 1 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| 29 | Roschon Johnson | Texas | JR | RB | 7 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| 29 | Malik Knowles | Kansas St | JR | WR | 5 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| 29 | Torry Locklin | Kansas | SO | WR | 8 | 2 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
| 29 | Keilan Robinson | Texas | JR | RB | 6 | 2 | 2 | 1 | 1 | 0 | 0 | 0 | 0 | 0 |
| 29 | Donovan Smith | Texas Tech | FR | QB | 6 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| 29 | Xavier White | Texas Tech | JR | RB | 6 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| 29 | Trevor Wilson | Kansas | SO | WR | 10 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| 42 | Gerry Bohanon | Baylor | JR | QB | 2 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| 42 | Jonathon Brooks | Texas | FR | RB | 2 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| 42 | Hudson Card | Texas | FR | QB | 5 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| 42 | Derius Davis | TCU | SR | WR | 7 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| 42 | Xavier Hutchinson | Iowa State | SR | WR | 6 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| 42 | Justin Johnson Jr. | WVU | FR | RB | 6 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| 42 | Andrew Mevis | Iowa State | SR | PK | 6 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| 42 | Marvin Mims | Oklahoma | SO | WR | 2 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| 42 | Behren Morton | Texas Tech | FR | QB | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |