2021 Big 12 Conference Leaders Sacks - Games vs. FBS Teams With Winning Record Only through 01/10/2022
| Name | Team | Yr | Pos | G | Sacks | Sack Yards | Sacks/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Collin Oliver | Okla St | FR | DE | 9 | 7.0 | 54 | 0.78 |
| 2 | Tyree Wilson | Texas Tech | JR | DL | 7 | 6.0 | 50 | 0.86 |
| 3 | Will McDonald IV | Iowa State | JR | DE | 7 | 7.0 | 45 | 1.00 |
| 3 | Dante Stills | WVU | SR | DL | 8 | 6.0 | 45 | 0.75 |
| 5 | Brock Martin | Okla St | SR | DE | 8 | 6.5 | 38 | 0.81 |
| 6 | Terrel Bernard | Baylor | SR | LB | 7 | 5.5 | 35 | 0.79 |
| 7 | Eyioma Uwazurike | Iowa State | SR | DE | 7 | 4.5 | 33 | 0.64 |
| 8 | Isaiah Thomas | Oklahoma | SR | DL | 5 | 4.5 | 31 | 0.90 |
| 9 | Bryson Jackson | Baylor | SR | OLB | 8 | 3.5 | 26 | 0.44 |
| 10 | Tony Bradford Jr. | Texas Tech | JR | DL | 5 | 3.5 | 22 | 0.70 |
| 10 | Nate Matlack | Kansas St | FR | DE | 6 | 2.5 | 22 | 0.42 |
| 12 | Ochaun Mathis | TCU | JR | DE | 7 | 3.0 | 21 | 0.43 |
| 12 | Jalen Pitre | Baylor | SR | S | 8 | 2.5 | 21 | 0.31 |
| 14 | Malcolm Lee | Kansas | SR | DL | 7 | 1.0 | 20 | 0.14 |
| 15 | Key Lawrence | Oklahoma | SO | DB | 6 | 1.0 | 18 | 0.17 |
| 16 | TJ Franklin | Baylor | JR | DL | 8 | 3.0 | 17 | 0.38 |
| 16 | Devin Harper | Okla St | SR | LB | 9 | 2.5 | 17 | 0.28 |
| 18 | Malcolm Rodriguez | Okla St | SR | LB | 9 | 2.0 | 16 | 0.22 |
| 19 | Gabe Hall | Baylor | SO | DL | 7 | 5.0 | 15 | 0.71 |
| 19 | Alfred Collins | Texas | SO | DL | 8 | 2.0 | 15 | 0.25 |
| 19 | Tyler Lacy | Okla St | JR | DE | 9 | 1.5 | 15 | 0.17 |
| 19 | Jarrick Bernard-Converse | Okla St | SR | CB | 9 | 1.5 | 15 | 0.17 |
| 19 | Jason Taylor II | Okla St | JR | S | 9 | 1.5 | 15 | 0.17 |
| 24 | Felix Anudike-Uzomah | Kansas St | SO | DE | 6 | 3.0 | 14 | 0.50 |
| 24 | Akheem Mesidor | WVU | SO | DL | 8 | 1.5 | 14 | 0.19 |
| 26 | Kyron Johnson | Kansas | SR | DE | 7 | 2.5 | 13 | 0.36 |
| 26 | Nik Bonitto | Oklahoma | JR | OLB | 5 | 2.0 | 13 | 0.40 |
| 26 | Daniel Green | Kansas St | JR | LB | 6 | 2.0 | 13 | 0.33 |
| 26 | Brayden Utley | Baylor | JR | DL | 8 | 2.0 | 13 | 0.25 |
| 26 | Jaylon Hutchings | Texas Tech | JR | DL | 7 | 1.5 | 13 | 0.21 |
| 26 | DeMarvion Overshown | Texas | SR | LB | 7 | 1.5 | 13 | 0.21 |
| 32 | Taijh Alston | WVU | JR | DL | 8 | 3.5 | 12 | 0.44 |
| 33 | Brendon Evers | Okla St | SR | DT | 9 | 2.5 | 11 | 0.28 |
| 33 | Jalen Redmond | Oklahoma | SO | DL | 5 | 2.0 | 11 | 0.40 |
| 33 | Jake Hummel | Iowa State | SR | LB | 7 | 1.0 | 11 | 0.14 |
| 33 | Blake Peterson | Iowa State | SO | DE | 7 | 1.0 | 11 | 0.14 |
| 33 | Caleb Sampson | Kansas | SR | DL | 7 | 1.0 | 11 | 0.14 |
| 33 | Matt Jones | Baylor | SO | LB | 8 | 1.0 | 11 | 0.13 |
| 33 | Dillon Doyle | Baylor | JR | LB | 8 | 1.0 | 11 | 0.13 |
| 40 | Josh Landry | Baylor | JR | DT | 7 | 1.0 | 10 | 0.14 |
| 40 | Raleigh Texada | Baylor | SR | CB | 8 | 1.0 | 10 | 0.13 |
| 40 | Jackie Matthews | WVU | JR | CB | 8 | 1.0 | 10 | 0.13 |
| 40 | Josh Chandler-Semedo | WVU | SR | LB | 8 | 1.0 | 10 | 0.13 |
| 44 | Timmy Horne | Kansas St | SR | DT | 6 | 2.0 | 9 | 0.33 |
| 44 | Reggie Stubblefield | Kansas St | SR | DB | 5 | 1.0 | 9 | 0.20 |
| 44 | Jett Bush | Texas | JR | LB | 6 | 1.0 | 9 | 0.17 |
| 44 | Nook Bradford | TCU | JR | S | 7 | 1.0 | 9 | 0.14 |
| 44 | Ben Kopenski | Okla St | JR | DE | 9 | 1.0 | 9 | 0.11 |
| 49 | Tre Sterling | Okla St | SR | S | 4 | 1.0 | 8 | 0.25 |
| 49 | Brian Asamoah | Oklahoma | JR | LB | 5 | 1.0 | 8 | 0.20 |