2021 Big 12 Conference Leaders Sacks - Games vs. Conference Teams Only through 01/10/2022
| Name | Team | Yr | Pos | G | Sacks | Sack Yards | Sacks/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Collin Oliver | Okla St | FR | DE | 10 | 10.0 | 69 | 1.00 |
| 2 | Will McDonald IV | Iowa State | JR | DE | 9 | 9.0 | 60 | 1.00 |
| 3 | Eyioma Uwazurike | Iowa State | SR | DE | 9 | 6.5 | 58 | 0.72 |
| 4 | Jason Taylor II | Okla St | JR | S | 10 | 2.5 | 41 | 0.25 |
| 5 | Felix Anudike-Uzomah | Kansas St | SO | DE | 9 | 8.0 | 38 | 0.89 |
| 6 | Dylan Horton | TCU | SR | DE | 9 | 4.0 | 37 | 0.44 |
| 7 | Isaiah Thomas | Oklahoma | SR | DL | 9 | 5.5 | 35 | 0.61 |
| 8 | Nik Bonitto | Oklahoma | JR | OLB | 9 | 4.5 | 32 | 0.50 |
| 9 | Devin Harper | Okla St | SR | LB | 10 | 4.5 | 30 | 0.45 |
| 10 | Dante Stills | WVU | SR | DL | 9 | 5.0 | 29 | 0.56 |
| 10 | Tyler Lacy | Okla St | JR | DE | 10 | 3.0 | 29 | 0.30 |
| 12 | Kyron Johnson | Kansas | SR | DE | 9 | 5.0 | 28 | 0.56 |
| 12 | Tyree Wilson | Texas Tech | JR | DL | 9 | 4.0 | 28 | 0.44 |
| 12 | Siaki Ika | Baylor | SO | DT | 10 | 4.0 | 28 | 0.40 |
| 12 | Akheem Mesidor | WVU | SO | DL | 9 | 3.5 | 28 | 0.39 |
| 16 | Brock Martin | Okla St | SR | DE | 9 | 4.5 | 27 | 0.50 |
| 16 | Terrel Bernard | Baylor | SR | LB | 9 | 3.5 | 27 | 0.39 |
| 16 | Nate Matlack | Kansas St | FR | DE | 9 | 3.0 | 27 | 0.33 |
| 19 | Gabe Hall | Baylor | SO | DL | 10 | 6.0 | 23 | 0.60 |
| 20 | Ochaun Mathis | TCU | JR | DE | 9 | 3.0 | 21 | 0.33 |
| 20 | Ben Davis | Texas | SR | EDG | 8 | 2.5 | 21 | 0.31 |
| 22 | Malcolm Rodriguez | Okla St | SR | LB | 10 | 3.0 | 20 | 0.30 |
| 22 | Blake Peterson | Iowa State | SO | DE | 9 | 2.0 | 20 | 0.22 |
| 22 | Malcolm Lee | Kansas | SR | DL | 9 | 1.0 | 20 | 0.11 |
| 25 | Perrion Winfrey | Oklahoma | SR | DL | 9 | 3.0 | 18 | 0.33 |
| 25 | Key Lawrence | Oklahoma | SO | DB | 9 | 1.0 | 18 | 0.11 |
| 27 | TJ Franklin | Baylor | JR | DL | 10 | 3.0 | 17 | 0.30 |
| 28 | Anthony Cook | Texas | SR | DB | 9 | 1.0 | 16 | 0.11 |
| 29 | Alfred Collins | Texas | SO | DL | 9 | 2.0 | 15 | 0.22 |
| 29 | Jarrick Bernard-Converse | Okla St | SR | CB | 10 | 1.5 | 15 | 0.15 |
| 31 | Brendon Evers | Okla St | SR | DT | 10 | 3.0 | 14 | 0.30 |
| 31 | Rich Miller | Kansas | JR | LB | 9 | 1.0 | 14 | 0.11 |
| 33 | Taijh Alston | WVU | JR | DL | 9 | 3.5 | 12 | 0.39 |
| 34 | Israel Antwine | Okla St | SR | DT | 10 | 3.0 | 11 | 0.30 |
| 34 | Josh Chandler-Semedo | WVU | SR | LB | 9 | 1.5 | 11 | 0.17 |
| 34 | Caleb Sampson | Kansas | SR | DL | 9 | 1.0 | 11 | 0.11 |
| 34 | Matt Jones | Baylor | SO | LB | 10 | 1.0 | 11 | 0.10 |
| 38 | Eli Huggins | Kansas St | SR | DT | 9 | 2.0 | 10 | 0.22 |
| 38 | Daniel Green | Kansas St | JR | LB | 9 | 2.0 | 10 | 0.22 |
| 38 | DeMarvion Overshown | Texas | SR | LB | 8 | 1.5 | 10 | 0.19 |
| 38 | Jaylon Hutchings | Texas Tech | JR | DL | 9 | 1.5 | 10 | 0.17 |
| 38 | Jalen Pitre | Baylor | SR | S | 10 | 1.5 | 10 | 0.15 |
| 38 | Victor Obi | Baylor | JR | OLB | 6 | 1.0 | 10 | 0.17 |
| 38 | Josh Landry | Baylor | JR | DT | 8 | 1.0 | 10 | 0.13 |
| 38 | Raleigh Texada | Baylor | SR | CB | 10 | 1.0 | 10 | 0.10 |
| 46 | Timmy Horne | Kansas St | SR | DT | 9 | 2.0 | 9 | 0.22 |
| 46 | Khari Coleman | TCU | SO | DE | 9 | 1.5 | 9 | 0.17 |
| 46 | Nook Bradford | TCU | JR | S | 8 | 1.0 | 9 | 0.13 |
| 49 | Zion DeBose | Kansas | SR | DE | 7 | 1.5 | 8 | 0.21 |
| 49 | Tre Sterling | Okla St | SR | S | 2 | 1.0 | 8 | 0.50 |