2021 Conference USA Leaders Total Offense - Games vs. FBS non-Power 5 Conference Teams Only through 01/10/2022
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Western Kentucky | 11 | 1161 | 4741 | 830 | 5902 | 7.11 | 536.5 |
| 2 | Marshall | 12 | 1868 | 3367 | 839 | 5235 | 6.24 | 436.3 |
| 3 | UTEP | 12 | 1527 | 3100 | 775 | 4627 | 5.97 | 385.6 |
| 4 | UTSA | 12 | 2242 | 2960 | 861 | 5202 | 6.04 | 433.5 |
| 5 | Florida International | 10 | 852 | 2715 | 643 | 3567 | 5.55 | 356.7 |
| 6 | Middle Tennessee | 11 | 1446 | 2509 | 784 | 3955 | 5.04 | 359.5 |
| 7 | Old Dominion | 11 | 1590 | 2448 | 753 | 4038 | 5.36 | 367.1 |
| 8 | Florida Atlantic | 10 | 1483 | 2413 | 670 | 3896 | 5.81 | 389.6 |
| 9 | Charlotte | 9 | 1260 | 2361 | 632 | 3621 | 5.73 | 402.3 |
| 10 | Louisiana Tech | 9 | 1028 | 2282 | 615 | 3310 | 5.38 | 367.8 |
| 11 | UAB | 11 | 2068 | 2266 | 686 | 4334 | 6.32 | 394.0 |
| 12 | North Texas | 11 | 2510 | 2076 | 882 | 4586 | 5.20 | 416.9 |
| 13 | Rice | 9 | 1220 | 1914 | 616 | 3134 | 5.09 | 348.2 |
| 14 | Southern Mississippi | 10 | 1077 | 1466 | 622 | 2543 | 4.09 | 254.3 |