2021 Conference USA Leaders Total Offense - Games vs. FBS (I-A) Teams Only through 01/10/2022
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Western Kentucky | 13 | 1326 | 5594 | 985 | 6920 | 7.03 | 532.3 |
| 2 | Marshall | 12 | 1868 | 3367 | 839 | 5235 | 6.24 | 436.3 |
| 3 | UTSA | 13 | 2459 | 3240 | 943 | 5699 | 6.04 | 438.4 |
| 4 | UTEP | 12 | 1527 | 3100 | 775 | 4627 | 5.97 | 385.6 |
| 5 | Florida International | 11 | 907 | 2906 | 701 | 3813 | 5.44 | 346.6 |
| 6 | Louisiana Tech | 11 | 1268 | 2891 | 756 | 4159 | 5.50 | 378.1 |
| 7 | Charlotte | 11 | 1492 | 2876 | 751 | 4368 | 5.82 | 397.1 |
| 8 | Middle Tennessee | 12 | 1512 | 2792 | 860 | 4304 | 5.00 | 358.7 |
| 9 | Florida Atlantic | 11 | 1575 | 2674 | 740 | 4249 | 5.74 | 386.3 |
| 10 | Old Dominion | 12 | 1735 | 2575 | 830 | 4310 | 5.19 | 359.2 |
| 11 | North Texas | 12 | 2698 | 2381 | 957 | 5079 | 5.31 | 423.3 |
| 12 | UAB | 12 | 2195 | 2313 | 739 | 4508 | 6.10 | 375.7 |
| 13 | Rice | 11 | 1445 | 2269 | 746 | 3714 | 4.98 | 337.6 |
| 14 | Southern Mississippi | 11 | 1159 | 1597 | 679 | 2756 | 4.06 | 250.5 |