2021 Conference USA Leaders Penalties - Games vs. FBS Power 5 Conference Teams Only through 01/10/2022
| Name | G | Pen. | Yards | Pen./G | Yards/G | |
|---|---|---|---|---|---|---|
| 1 | UTSA | 1 | 3 | 43 | 3.0 | 43.0 |
| 2 | Southern Mississippi | 1 | 5 | 36 | 5.0 | 36.0 |
| 2 | Florida International | 1 | 5 | 45 | 5.0 | 45.0 |
| 4 | Florida Atlantic | 1 | 6 | 28 | 6.0 | 28.0 |
| 4 | North Texas | 1 | 6 | 45 | 6.0 | 45.0 |
| 4 | Middle Tennessee | 1 | 6 | 62 | 6.0 | 62.0 |
| 7 | Charlotte | 2 | 14 | 112 | 7.0 | 56.0 |
| 8 | Louisiana Tech | 2 | 15 | 98 | 7.5 | 49.0 |
| 9 | Rice | 2 | 16 | 100 | 8.0 | 50.0 |
| 9 | Old Dominion | 1 | 8 | 56 | 8.0 | 56.0 |
| 11 | Western Kentucky | 2 | 17 | 134 | 8.5 | 67.0 |
| 12 | UAB | 1 | 11 | 78 | 11.0 | 78.0 |