2021 Conference USA Leaders Interceptions - Games vs. FBS (I-A) Teams Only through 01/10/2022
| Name | G | Int. | Yards | TD | Int./G | |
|---|---|---|---|---|---|---|
| 1 | UTSA | 13 | 12 | 200 | 3 | 0.92 |
| 1 | Southern Mississippi | 11 | 10 | 137 | 3 | 0.91 |
| 3 | Western Kentucky | 13 | 20 | 190 | 2 | 1.54 |
| 3 | Middle Tennessee | 12 | 16 | 270 | 2 | 1.33 |
| 3 | UAB | 12 | 10 | 218 | 2 | 0.83 |
| 3 | Charlotte | 11 | 8 | 44 | 2 | 0.73 |
| 7 | Florida Atlantic | 11 | 11 | 144 | 1 | 1.00 |
| 7 | Louisiana Tech | 11 | 7 | 149 | 1 | 0.64 |
| 7 | Old Dominion | 12 | 7 | 119 | 1 | 0.58 |
| 10 | Rice | 11 | 13 | 45 | 0 | 1.18 |
| 10 | Marshall | 12 | 10 | 163 | 0 | 0.83 |
| 10 | UTEP | 12 | 7 | 28 | 0 | 0.58 |
| 10 | North Texas | 12 | 5 | 114 | 0 | 0.42 |
| 10 | Florida International | 11 | 3 | 0 | 0 | 0.27 |