2021 Conference USA Leaders Passes Defended - Games in October Only through 01/10/2022
| Name | G | Int. | Passes Broken Up | Passes Defended | Passes Defended/G | |
|---|---|---|---|---|---|---|
| 1 | Western Kentucky | 5 | 4 | 27 | 31 | 6.20 |
| 2 | Florida Atlantic | 4 | 5 | 22 | 27 | 6.75 |
| 3 | Old Dominion | 4 | 3 | 21 | 24 | 6.00 |
| 4 | Middle Tennessee State | 4 | 10 | 19 | 29 | 7.25 |
| 5 | Rice | 4 | 5 | 18 | 23 | 5.75 |
| 6 | UTEP | 4 | 5 | 17 | 22 | 5.50 |
| 7 | UTSA | 4 | 7 | 14 | 21 | 5.25 |
| 8 | Charlotte | 4 | 3 | 12 | 15 | 3.75 |
| 8 | Louisiana Tech | 4 | 2 | 12 | 14 | 3.50 |
| 10 | Southern Miss | 4 | 2 | 10 | 12 | 3.00 |
| 11 | Marshall | 4 | 6 | 9 | 15 | 3.75 |
| 11 | North Texas | 4 | 1 | 9 | 10 | 2.50 |
| 13 | UAB | 4 | 4 | 8 | 12 | 3.00 |
| 14 | FIU | 4 | 0 | 5 | 5 | 1.25 |