2021 Conference USA Leaders Passes Defended - Games vs. FBS Teams With Non-Winning Record Only through 01/10/2022
| Name | G | Int. | Passes Broken Up | Passes Defended | Passes Defended/G | |
|---|---|---|---|---|---|---|
| 1 | UTEP | 8 | 6 | 38 | 44 | 5.50 |
| 2 | Western Kentucky | 6 | 10 | 32 | 42 | 7.00 |
| 2 | Middle Tennessee | 7 | 8 | 32 | 40 | 5.71 |
| 4 | UAB | 6 | 7 | 22 | 29 | 4.83 |
| 4 | Florida Atlantic | 5 | 6 | 22 | 28 | 5.60 |
| 6 | Southern Mississippi | 6 | 5 | 20 | 25 | 4.17 |
| 7 | Rice | 5 | 8 | 19 | 27 | 5.40 |
| 7 | Old Dominion | 5 | 3 | 19 | 22 | 4.40 |
| 9 | Charlotte | 7 | 5 | 17 | 22 | 3.14 |
| 10 | UTSA | 7 | 7 | 15 | 22 | 3.14 |
| 11 | Marshall | 6 | 8 | 14 | 22 | 3.67 |
| 12 | Louisiana Tech | 5 | 4 | 12 | 16 | 3.20 |
| 12 | Florida International | 6 | 2 | 12 | 14 | 2.33 |
| 12 | North Texas | 5 | 1 | 12 | 13 | 2.60 |